| | | |
Disease Unset
|
|---|
| | | |
Days after inoculation with LCM Virus
|
|---|
| |
Survival (days)
|
Weight loss (grams)
|
Decreased mobility
|
Convulsions
|
Hair disheveled
|
|---|
|
Vehicle
| | | | | |
|
Mouse #1*
|
<<1
|
NA
|
0
|
NA
|
NA
|
|
Mouse #2*
|
<<1
|
NA
|
0
|
NA
|
NA
|
|
Mouse #3*
|
<<1
|
NA
|
0
|
NA
|
NA
|
|
Mouse #4
|
6
|
1.5
|
4.5
|
5.5
|
4.5
|
|
Mouse #5
|
6
|
2
|
4.5
|
5.5
|
4.5
|
|
Mouse #6
|
7
|
2
|
5
|
6
|
5
|
|
Mouse #7
|
7
|
1.5
|
5
|
6
|
5
|
|
Mouse #8
|
7
|
2.5
|
5
|
6
|
5
|
|
Mouse #9
|
7
|
4.5
|
5
|
6
|
5
|
|
Mouse #10
|
7
|
4.5
|
5
|
6
|
5
|
|
Mouse #11
|
7
|
4.5
|
5
|
6
|
5
|
|
Mouse #12
|
8
|
2
|
6
|
7
|
6
|
|
Mouse #13
|
8
|
2.5
|
6
|
7
|
6
|
|
Mouse #14
|
8
|
1
|
6
|
7
|
6
|
|
Mouse #15
|
8
|
1.5
|
6
|
7
|
6
|
|
Mouse #16
|
8
|
2
|
6
|
7
|
6
|
|
Mouse #17
|
8
|
2
|
6
|
7
|
6
|
|
Mouse #18
|
7
|
1.5
|
5
|
6
|
5
|
|
Mouse #19
|
8
|
2
|
6
|
7
|
6
|
|
Mouse #20
|
8
|
1.5
|
6
|
7
|
6
|
|
PAP 0.25 mg/kg
| | | | | |
|
Mouse #1
|
<<1
|
NA
|
NA
|
NA
|
NA
|
|
Mouse #2
|
<<1
|
NA
|
NA
|
NA
|
NA
|
|
Mouse #3
|
6
|
1
|
4.5
|
5.5
|
5
|
|
Mouse #4
|
7
|
1.5
|
5
|
6
|
5
|
|
Mouse #5
|
8
|
1.5
|
6
|
7
|
5.5
|
|
Mouse #6
|
21
|
0
|
10
|
NO
|
NO
|
|
Mouse #7
|
21
|
0
|
10
|
NO
|
NO
|
|
Mouse #8
|
21
|
0
|
10
|
NO
|
NO
|
|
Mouse #9
|
21
|
0
|
10
|
NO
|
NO
|
|
Mouse #10
|
21
|
0
|
10
|
NO
|
NO
|
- *Mouse died after intracerebral injection; NA = not applicable, NO = not observed
