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Table 6 MIC range, and MIC50 and MIC90 values of selected primary baseline isolates (ME population)

From: A multicenter trial of the efficacy and safety of tigecycline versus imipenem/cilastatin in patients with complicated intra-abdominal infections [Study ID Numbers: 3074A1-301-WW; ClinicalTrials.gov Identifier: NCT00081744]

  

Tigecycline

Imipenem/Cilastatin

Isolate

n

MIC range

MIC50

MIC90

MIC range

MIC50

MIC90

Bacteroides fragilis

83

0.06–16.0

1.0

2.0

0.12–4.0

0.25

0.5

Clostridium perfringens

12

0.06–2.0

1.0

2.0

0.12–0.25

0.12

0.25

Enterococcus faecalis (non-VRE)

32

0.06–0.25

0.12

0.25

1.0–4.0

1.0

4.0

Escherichia coli

350

0.06–1.0

0.25

0.50

0.12–1.0

0.12

0.25

Klebsiella pneumoniae

58

0.25–2.0

0.50

1.00

0.12–0.50

0.25

0.25

Pseudomonas aeruginosa

39

8.0–32.0

16.0

32.0

0.25–4.0

1.0

2.0

Staphylococcus aureus (MRSA)

3

0.12–0.25

NA

NA

0.12–32.0

NA

NA

S. aureus (non-MRSA)

12

0.12–0.50

0.25

0.25

0.12–0.12

0.12

0.12

  1. NA = MIC50 and MIC90 values are not valid if the number of isolates is less than 10.
  2. MRSA = methicillin-resistant Staphylococcus aureus.
  3. VRE = vancomycin-resistant enterococci.