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Table 3 Positive and negative predictive values of HSV-2 test approaches by population prevalence

From: Use of "biokitHSV-2 Rapid Assay" to improve the positive predictive value of Focus HerpeSelect HSV-2 ELISA

  Positive Predictive Value
True Prevalence Focus HSV-2 ELISA Biokit Focus HSV-2 ELISA+Biokit
10 61.9% 86.5% 89.8%
20 78.5% 93.5% 95.2%
30 86.3% 96.1% 97.1%
40 90.7% 97.5% 98.1%
50 93.6% 98.3% 98.8%
70 97.2% 99.3% 99.5%
90 99.2% 99.8% 99.9%
  Negative Predictive Value
10 99.9% 98.9% 99.9%
20 99.8% 97.7% 99.8%
30 99.6% 96.0% 99.6%
40 99.4% 94.0% 99.4%
50 99.1% 91.2% 99.1%
70 98.0% 81.7% 97.9%
90 92.5% 53.6% 92.3%
  1. Ranges indicated show the confidence intervals for accuracy; these also incorporate the uncertainty from having confirmed only a portion of Focus negatives. Biokit was used to confirm all sera that were initially positive for HSV-2 antibodies by Focus HSV-2 ELISA; the combined test results are shown in the "Focus Plus Biokit" column.
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