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Table 2 Estimated sensitivity and specificity of HSV-2 tests

From: Use of "biokitHSV-2 Rapid Assay" to improve the positive predictive value of Focus HerpeSelect HSV-2 ELISA

  Focus Biokit Focus Plus Biokit
Sensitivity 99.2 (96.3,100.0) 90.5 (86.1,94.0) 99.1 (96,100.0)
Specificity 93.2 (91.8,94.6) 98.4 (97.5,99.3) 98.7 (98.1,99.4)
Positive Predictive Value 80.5 (76.9,84.2) 94.5 (90.5,97.3) 95.6 (93.4,97.8)
Negative Predictive Value 99.7 (98.9,100.0) 97.5 (96.6,98.4) 99.7 (98.9,100.0)
  1. Ranges indicated show the confidence intervals for accuracy; these also incorporate the uncertainty from having confirmed only a portion of Focus negatives. Biokit was used to confirm all sera that were initially positive for HSV-2 antibodies by Focus HSV-2 ELISA; the combined test results are shown in the "Focus Plus Biokit" column.
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