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Table 4 Multivariate logistic regression analysis of factors associated with sustained viral response to interferon-alpha therapy in chronic hepatitis C patients

From: High versus standard doses interferon-alpha in the treatment of naïve chronic hepatitis C patients in Taiwan: a 10-year cohort study

Variable†

 

Odds ratio

95% CI‡

Pretreatment HCV RNA level§

Per 1 log increase

0.179

0.096–0.336

HCV genotype

1b = 1; non-1b = 0

0.324

0.151–0.695

IFN-α regimen

6-MU = 1; 3-MU = 0¶

2.310

1.070–4.990

Stage of fibrosis

F3–4 = 1; F0–2 = 0

0.408

0.104–0.892

  1. † Factors included, age, sex, history of transfusion, pretreatment serum level of alanine aminotransferase and hepatitis C virus RNA, hepatitis C virus genotype, total necroinflammatory activity score, fibrosis score, interferon preparation, and interferon dose.
  2. ‡ CI: confidence interval.
  3. § HCV: hepatitis C virus.
  4. ¶ 3-MU group: interferon-α 3 million units thrice weekly for 24 weeks; 6-MU group: interferon-α 6 million units thrice weekly for 24 weeks.
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BMC Infectious Diseases

ISSN: 1471-2334

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