From: Outcome of infections due to pandrug-resistant (PDR) Gram-negative bacteria
Patient no. | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
Isolated organism | Pseudomonas aeruginosa | Pseudomonas aeruginosa | Pseudomonas aeruginosa | Klebsiella pneumoniae | Klebsiella pneumoniae | Pseudomonas aeruginosa | Pseudomonas aeruginosa |
Site of isolation | Bronchial secretions | Cerebrospinal fluid | Bronchial secretions | Tip of central venous catheter | Bronchial secretions | Urine | Blood |
Date of isolation (mo/dd/year) | 08/07/2001 | 07/17/2002 | 07/29/2003 | 01/16/2004 | 01/30/ 2004 | 04/16/ 2004 | Â |
Days in the ICU until the isolation of the pandrug-resistant strain | 40 | 62 | 34 | 33 | 52 | 32 | 0 |
Prior colistin use (days) | 0 | 23 | 11 | 33 | 31 | 6 | 0 |
Antibiotic combination used after isolation | Colistin + imipenem/ cilastatin, Colistin + meropenem, Colistin + ofloxacin | Two days prior to the isolation, all antibiotics had been stopped | Colistin + meropenem + ofloxacin + gentamicin | Colistin + meropenem | Colistin + ampicillin/sulbactam + trimethoprim/sulfamethoxazole | Colistin + ceftazidime | Piperacillin/tazobactam |
Dosage/Duration of colistin | 2 million IU q8h iv for 35 days, 1 million IU q8h iv for 17 days | 1 million IU q8h iv for 23 days | 3 million IU q8h iv for 37 days, 1 million IU q8h nebulized for 11 days | 2 million IU q8h iv for 16 days, 1 million IU q8h iv for 12 days, 1 million IU q12h iv for 19 days | 1 million IU q8h iv for 34 days | 2 million IU q8h in for 35 days, 1 million IU q8h iv for 17 days | 2.25 gr q8h iv for 10 days |
Outcome of the infection | Cure (clinical + microbiological). | No response. Patient died due to meningitis. | Cure (clinical + microbiological). | Clinical cure (microbiological persistence for 1 month). | Deterioration. Superinfection of the respiratory tract by an Acinetobacter baumannii strain. Patient died due to sepsis. | Cure (clinical + microbiological). | Cure (clinical + microbiological). |