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Table 1 Characteristics of the reported patients and outcomes of the infections.

From: Outcome of infections due to pandrug-resistant (PDR) Gram-negative bacteria

Patient no.

1

2

3

4

5

6

7

Isolated organism

Pseudomonas aeruginosa

Pseudomonas aeruginosa

Pseudomonas aeruginosa

Klebsiella pneumoniae

Klebsiella pneumoniae

Pseudomonas aeruginosa

Pseudomonas aeruginosa

Site of isolation

Bronchial secretions

Cerebrospinal fluid

Bronchial secretions

Tip of central venous catheter

Bronchial secretions

Urine

Blood

Date of isolation (mo/dd/year)

08/07/2001

07/17/2002

07/29/2003

01/16/2004

01/30/ 2004

04/16/ 2004

 

Days in the ICU until the isolation of the pandrug-resistant strain

40

62

34

33

52

32

0

Prior colistin use (days)

0

23

11

33

31

6

0

Antibiotic combination used after isolation

Colistin + imipenem/ cilastatin, Colistin + meropenem, Colistin + ofloxacin

Two days prior to the isolation, all antibiotics had been stopped

Colistin + meropenem + ofloxacin + gentamicin

Colistin + meropenem

Colistin + ampicillin/sulbactam + trimethoprim/sulfamethoxazole

Colistin + ceftazidime

Piperacillin/tazobactam

Dosage/Duration of colistin

2 million IU q8h iv for 35 days, 1 million IU q8h iv for 17 days

1 million IU q8h iv for 23 days

3 million IU q8h iv for 37 days, 1 million IU q8h nebulized for 11 days

2 million IU q8h iv for 16 days, 1 million IU q8h iv for 12 days, 1 million IU q12h iv for 19 days

1 million IU q8h iv for 34 days

2 million IU q8h in for 35 days, 1 million IU q8h iv for 17 days

2.25 gr q8h iv for 10 days

Outcome of the infection

Cure (clinical + microbiological).

No response.

Patient died due to meningitis.

Cure (clinical + microbiological).

Clinical cure (microbiological persistence for 1 month).

Deterioration.

Superinfection of the respiratory tract by an Acinetobacter baumannii strain. Patient died due to sepsis.

Cure (clinical + microbiological).

Cure (clinical + microbiological).