A randomised controlled trial of the effects of albendazole in pregnancy on maternal responses to mycobacterial antigens and infant responses to bacille Calmette-Guérin (BCG) immunisation [ISRCTN32849447]

Table 1 Factors associated with high IFN-γ responses to mycobacterial antigens among mothers and their infants.

Maternal variables in pregnancy	Mothers during pregnancy n = 90		Infants at one year of age n = 57
	Proportion (%) with "high IFN-γ" (> median^a)	P value	Proportion (%) with "high IFN-γ" (> median^a)	P value
Helminths
none	12/19 (63%)		4/17 (24%)
hookworm	11/36 (31%)	0.025	16/20 (80%)	0.001
S. mansoni	12/22 (55%)	0.75	7/12 (58%)	0.12
HIV infection
Negative	39/78 (50%)		26/49 (53%)
positive	5/12 (42%)	0.76	3/8 (38%)	0.47
Malaria parasitaemia
Negative	41/77 (53%)		25/49 (51%)
Positive	3/13 (23%)	0.07	4/8 (50%)	1.00
Age
< 25 years	28/61 (46%)		19/37 (51%)
25 or older	16/29 (55%)	0.50	10/20 (50%)	1.00
Education (1 mv)
none/ primary	29/55 (53%)		19/34 (56%)
secondary/ tertiary	15/34 (44%)	0.52	10/23 (43%)	0.42
BCG scar (3 mv)
absent	11/28 (39%)		10/14 (71%)
present	32/59 (54%)	0.25	18/41 (44%)	0.12

^a The median level of IFN-γ production in response to CFP for mothers was 69 pg/ml; for infants 206 pg/ml. mv: missing values

ISSN: 1471-2334