TY - JOUR AU - Van Weyenbergh, Johan AU - Santana, Gisélia AU - D'Oliveira, Argemiro AU - Santos, Anibal F. AU - Costa, Carlos H. AU - Carvalho, Edgar M. AU - Barral, Aldina AU - Barral-Netto, Manoel PY - 2004 DA - 2004/11/17 TI - Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study JO - BMC Infectious Diseases SP - 50 VL - 4 IS - 1 AB - The process of elimination of intracellular pathogens, such as Leishmania, requires a Th1 type immune response, whereas a dominant Th2 response leads to exacerbated disease. Experimental human zinc deficiency decreases Th1 but not Th2 immune response. We investigated if zinc and copper levels differ in different clinical forms of leishmaniasis, and if these trace metals might be involved in the immune response towards the parasite. SN - 1471-2334 UR - https://doi.org/10.1186/1471-2334-4-50 DO - 10.1186/1471-2334-4-50 ID - Van Weyenbergh2004 ER -