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Table 5 Addition of the 4995 mutation further attenuates rDEN2Δ30 in SCID-HuH-7 mice.

From: Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2

  Replication in SCID-HuH-7 micea
Virus No. of mice Mean virus titer (log10PFU/ml ± SE)
DEN-2 Tonga/74 6 5.9 ± 0.3
rDEN-2 15 6.4 ± 0.2
rDEN2Δ30 22 5.2 ± 0.1
rDEN2Δ30-4995 28 4.6 ± 0.2
  1. a Groups of HuH-7-SCID mice were inoculated directly into the tumor with 104 PFU virus. Serum was collected on day 7 and titered in Vero cells. Data is included from three separate experiments.