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Table 2 Addition of the Δ30 mutation to rDEN-2 decreases replication in SCID-HuH-7 mice by 10-fold.

From: Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2

  Replication in SCID-HuH-7 micea
Virus No. of mice Mean virus titer (log10PFU/ml ± SE)
DEN-2 Tonga/74 6 5.9 ± 0.3
rDEN-2 7 5.9 ± 0.2
rDEN2Δ30 9 4.9 ± 0.2
  1. a Groups of HuH-7-SCID mice were inoculated directly into the tumor with 104 PFU virus. Serum was collected on day 7 and tittered in Vero cells.