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Table 1 Missense and UTR mutations which arose spontaneously in rDEN-2 and rDEN2Δ30 viruses during passage in Vero cells.

From: Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2

Virus Gene Nucleotide position Nucleotide substitution Amino acid positiona Amino acid change
rDEN-2 NS4B 7169b U > C 115 Val > Ala
  NS5 9248 A > C 560 Glu > Ala
rDEN2Δ30 NS4B 7169b U > C 115 Val > Ala
rDEN2Δ30-4995 NS3 4949 A > G 143 Lys > Arg
  NS4B 7169b U > C 115 Val > Ala
  3' UTR 10322 G > A -- --
  1. a Amino acid position in the individual DEN-2 protein.
  2. b Nucleotide position 7169 in DEN-2 corresponds to nt 7162 in rDEN-4, and the wild-type amino acid is Val and Leu, respectively [23].