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Table 1 Missense and UTR mutations which arose spontaneously in rDEN-2 and rDEN2Δ30 viruses during passage in Vero cells.

From: Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2

Virus

Gene

Nucleotide position

Nucleotide substitution

Amino acid positiona

Amino acid change

rDEN-2

NS4B

7169b

U > C

115

Val > Ala

 

NS5

9248

A > C

560

Glu > Ala

rDEN2Δ30

NS4B

7169b

U > C

115

Val > Ala

rDEN2Δ30-4995

NS3

4949

A > G

143

Lys > Arg

 

NS4B

7169b

U > C

115

Val > Ala

 

3' UTR

10322

G > A

--

--

  1. a Amino acid position in the individual DEN-2 protein.
  2. b Nucleotide position 7169 in DEN-2 corresponds to nt 7162 in rDEN-4, and the wild-type amino acid is Val and Leu, respectively [23].