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Table 1 Representation of selected immune-related genes upregulated during the first 12 hours post-infection.

From: A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection

Gene Unique Gene ID. Function Expression range (log2) Cluster no.
Immune Response Genes:
TGFBR1 Hs.220 Cytokine proinflammatory 10.66 4
CD36 Hs.75613 Macrophage receptor 8.61 3
TLR 9 Hs.87968 Macrophage activation 7.11 7
MST Hs.349110 Macrophage activation 7.07 6
IL 19 Hs.71979 Cytokine, proinflammatory 6.86 9
C1QR Hs.97199 Innate response 6.31 7
C6 Hs.1282 Innate response 6.22 6
GATA3 Hs.169946 Inflamation signaling 6.14 9
MMD Hs.79889 Monocyte to macrophage 6.13 7
CCL 25 Hs.50404 Chemokine, trafficking 6.10 6
CXCL 12 Hs.237356 Chemokine, trafficking 5.86 6
CCL 27 Hs.225948 Chemokine, trafficking 5.34 6
C4BPB Hs.99886 Innate response 5.12 6
CCR 4 Hs.184926 Chemokine, trafficking 5.11 3
CCL 4 Hs.75703 Chemokine, trafficking 4.62 3
IL 17C Hs.110040 Chemokine, trafficking 4.25 14
IL 1β Hs.126256 Cytokine, proinflammatory 4.20 3
MRC 2 Hs.7835 Macrophage activation 3.20 7
CXCL 9 Hs.77367 Chemokine, trafficking 3.00 2
CCL 20 Hs.75498 Chemokine, trafficking 2.88 3
CXCL 3 Hs.89690 Chemokine, trafficking 2.79 13
CXCL 2 Hs.75765 Chemokine, trafficking 2.78 3
CD 14 Hs.75627 Macrophage activation 2.73 3
IL 8 Hs.624 Chemokine, trafficking 2.70 3
NFκβ1 Hs.83428 Macrophage activation 2.61 13
CCL 22 Hs.97203 Chemokine, trafficking 2.60 3
CCR 7 Hs.1652 Chemokine, trafficking 2.55 9
Blood Coagulation Genes:
SERPINA3 Hs.234726 Inflammation activation 9.39 3
SERPINI2 Hs.158308 Proteinase inhibitor 8.82 11
TBXAS 1 Hs.2001 Blood coagulation 7.70 8
FGB Hs.7645 Fibrin 6.75 4
SERPIND1 Hs.1478 Blood coagulation 6.69 14
SERPINI1 Hs.78589 Proteinase inhibitor 6.68 6
SERPINA7 Hs.76838 Proteinase inhibitor 6.60 7
GP1bα Hs.1472 Platelet aggregation 5.68 6
PROC Hs.2351 Blood coagulation 5.63 6
Factor 10 Hs.47913 Blood coagulation 4.66 6
Factor 2 Hs.76530 Blood coagulation 4.50 6
GP 9 Hs.1144 Platelet aggregation 4.02 6
Factor 3 Hs.62192 Blood coagulation 3.60 2
FGG Hs.75431 Fibrin 2.60 3
SEPPINE1 Hs.82085 Anti-Fibrinolysis 1.75 9
Signaling Genes:
UNC 13 Hs.155001 Apoptosis induction 11.19 4
CARD 4 Hs.19405 Apoptosis, caspase activator 10.68 14
TNFRSF17 Hs.2556 Apoptosis signaling 10.19 14
ARL 1 Hs.242894 Cell-cell signaling 8.66 2
LGALS 3 Hs.79339 Signaling, scavenger activity 7.65 6
FAT Hs.166994 Tumour suppressor 7.15 2
TNFSF9 Hs.1524 Apoptosis signaling 6.85 6
BBC3 Hs.87246 Apoptosis signaling 6.77 9
TNFRSF13β Hs.158341 Apoptosis signaling 6.49 6
DDX24 Hs.155986 Apoptosis signaling 6.11 6
TNFRSF11β Hs.81791 Apoptosis signaling 6.11 7
TNFRSF10β Hs.51233 Apoptosis signaling 6.09 6
BNIP2 Hs.155596 Apoptosis signaling 5.81 1
MGST 2 Hs.81874 Cell-cell signaling 5.50 6
CUL 4 Hs.183874 Tumour suppressor 5.35 6
BAF 53A Hs.274350 Cell-cell signaling 5.26 6
MAPK 1 Hs.324473 Apoptosis induction 5.11 14
CUL 2 Hs.82919 Tumour suppressor 5.09 6
P2RX 1 Hs.41735 Apoptosis, ion channel activity 4.43 6
TYROBP Hs.9963 Intracellular receptor signaling 2.51 13
CNIH Hs.201673 Intracellular signaling 2.13 9
ADRα1A Hs.52931 Cell-cell signaling 2.08 3
DAPK 1 Hs.153924 Apoptosis induction 2.01 9
Defense-related Genes:
TFF 1 Hs.350470 Defense response, maintenance 7.65 9
TFF 3 Hs.82961 Extracellular defense response 6.98 7
GAGE 1 Hs.128231 Cellular defense response 6.82 6
DEFβ3 Hs.283082 Extracellular defense response 6.01 5
RU 2 Hs.61345 Extracellular defense response 5.83 6
DEFα4 Hs.2582 Extracellular defense response 5.81 6
Interferons-related Genes:
IFNαR1 Hs.1513 JAK-STAT cascade, recptor 5.41 8
IRF 7 Hs.166120 Transcription regulation 5.05 6
IF 144 Hs.82316 Invasive growth response 2.69 5
IRF 6 Hs.11801 Transcription regulation 2.06 14
IL 18 Hs.83077 Angiogenesis 1.76 6
ISGF3γ Hs.1706 Regulatory 1.28 9
IRF 5 Hs.334450 Transcription regulation 1.23 9
IFNαR2 Hs.86958 Receptor activity 1.06 2
IFNγR1 Hs.180866 Receptor activity 0.80 5
IFNγ Hs.856 Growth regulation 0.53 4
IRF 3 Hs.75254 Transcription regulation 0.40 5
IRF 2 Hs.83795 Transcription regulation 0.32 4
IRF 1 Hs.80645 Transcription regulation 0.30 3
  1. Order is arranged from the highest to lowest value based on the expression range (log2).
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BMC Infectious Diseases

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