Table 1 Representation of selected immune-related genes upregulated during the first 12 hours post-infection.
Gene | Unique Gene ID. | Function | Expression range (log2) | Cluster no. |
|---|---|---|---|---|
Immune Response Genes: | ||||
TGFBR1 | Hs.220 | Cytokine proinflammatory | 10.66 | 4 |
CD36 | Hs.75613 | Macrophage receptor | 8.61 | 3 |
TLR 9 | Hs.87968 | Macrophage activation | 7.11 | 7 |
MST | Hs.349110 | Macrophage activation | 7.07 | 6 |
IL 19 | Hs.71979 | Cytokine, proinflammatory | 6.86 | 9 |
C1QR | Hs.97199 | Innate response | 6.31 | 7 |
C6 | Hs.1282 | Innate response | 6.22 | 6 |
GATA3 | Hs.169946 | Inflamation signaling | 6.14 | 9 |
MMD | Hs.79889 | Monocyte to macrophage | 6.13 | 7 |
CCL 25 | Hs.50404 | Chemokine, trafficking | 6.10 | 6 |
CXCL 12 | Hs.237356 | Chemokine, trafficking | 5.86 | 6 |
CCL 27 | Hs.225948 | Chemokine, trafficking | 5.34 | 6 |
C4BPB | Hs.99886 | Innate response | 5.12 | 6 |
CCR 4 | Hs.184926 | Chemokine, trafficking | 5.11 | 3 |
CCL 4 | Hs.75703 | Chemokine, trafficking | 4.62 | 3 |
IL 17C | Hs.110040 | Chemokine, trafficking | 4.25 | 14 |
IL 1β | Hs.126256 | Cytokine, proinflammatory | 4.20 | 3 |
MRC 2 | Hs.7835 | Macrophage activation | 3.20 | 7 |
CXCL 9 | Hs.77367 | Chemokine, trafficking | 3.00 | 2 |
CCL 20 | Hs.75498 | Chemokine, trafficking | 2.88 | 3 |
CXCL 3 | Hs.89690 | Chemokine, trafficking | 2.79 | 13 |
CXCL 2 | Hs.75765 | Chemokine, trafficking | 2.78 | 3 |
CD 14 | Hs.75627 | Macrophage activation | 2.73 | 3 |
IL 8 | Hs.624 | Chemokine, trafficking | 2.70 | 3 |
NFκβ1 | Hs.83428 | Macrophage activation | 2.61 | 13 |
CCL 22 | Hs.97203 | Chemokine, trafficking | 2.60 | 3 |
CCR 7 | Hs.1652 | Chemokine, trafficking | 2.55 | 9 |
Blood Coagulation Genes: | ||||
SERPINA3 | Hs.234726 | Inflammation activation | 9.39 | 3 |
SERPINI2 | Hs.158308 | Proteinase inhibitor | 8.82 | 11 |
TBXAS 1 | Hs.2001 | Blood coagulation | 7.70 | 8 |
FGB | Hs.7645 | Fibrin | 6.75 | 4 |
SERPIND1 | Hs.1478 | Blood coagulation | 6.69 | 14 |
SERPINI1 | Hs.78589 | Proteinase inhibitor | 6.68 | 6 |
SERPINA7 | Hs.76838 | Proteinase inhibitor | 6.60 | 7 |
GP1bα | Hs.1472 | Platelet aggregation | 5.68 | 6 |
PROC | Hs.2351 | Blood coagulation | 5.63 | 6 |
Factor 10 | Hs.47913 | Blood coagulation | 4.66 | 6 |
Factor 2 | Hs.76530 | Blood coagulation | 4.50 | 6 |
GP 9 | Hs.1144 | Platelet aggregation | 4.02 | 6 |
Factor 3 | Hs.62192 | Blood coagulation | 3.60 | 2 |
FGG | Hs.75431 | Fibrin | 2.60 | 3 |
SEPPINE1 | Hs.82085 | Anti-Fibrinolysis | 1.75 | 9 |
Signaling Genes: | ||||
UNC 13 | Hs.155001 | Apoptosis induction | 11.19 | 4 |
CARD 4 | Hs.19405 | Apoptosis, caspase activator | 10.68 | 14 |
TNFRSF17 | Hs.2556 | Apoptosis signaling | 10.19 | 14 |
ARL 1 | Hs.242894 | Cell-cell signaling | 8.66 | 2 |
LGALS 3 | Hs.79339 | Signaling, scavenger activity | 7.65 | 6 |
FAT | Hs.166994 | Tumour suppressor | 7.15 | 2 |
TNFSF9 | Hs.1524 | Apoptosis signaling | 6.85 | 6 |
BBC3 | Hs.87246 | Apoptosis signaling | 6.77 | 9 |
TNFRSF13β | Hs.158341 | Apoptosis signaling | 6.49 | 6 |
DDX24 | Hs.155986 | Apoptosis signaling | 6.11 | 6 |
TNFRSF11β | Hs.81791 | Apoptosis signaling | 6.11 | 7 |
TNFRSF10β | Hs.51233 | Apoptosis signaling | 6.09 | 6 |
BNIP2 | Hs.155596 | Apoptosis signaling | 5.81 | 1 |
MGST 2 | Hs.81874 | Cell-cell signaling | 5.50 | 6 |
CUL 4 | Hs.183874 | Tumour suppressor | 5.35 | 6 |
BAF 53A | Hs.274350 | Cell-cell signaling | 5.26 | 6 |
MAPK 1 | Hs.324473 | Apoptosis induction | 5.11 | 14 |
CUL 2 | Hs.82919 | Tumour suppressor | 5.09 | 6 |
P2RX 1 | Hs.41735 | Apoptosis, ion channel activity | 4.43 | 6 |
TYROBP | Hs.9963 | Intracellular receptor signaling | 2.51 | 13 |
CNIH | Hs.201673 | Intracellular signaling | 2.13 | 9 |
ADRα1A | Hs.52931 | Cell-cell signaling | 2.08 | 3 |
DAPK 1 | Hs.153924 | Apoptosis induction | 2.01 | 9 |
Defense-related Genes: | ||||
TFF 1 | Hs.350470 | Defense response, maintenance | 7.65 | 9 |
TFF 3 | Hs.82961 | Extracellular defense response | 6.98 | 7 |
GAGE 1 | Hs.128231 | Cellular defense response | 6.82 | 6 |
DEFβ3 | Hs.283082 | Extracellular defense response | 6.01 | 5 |
RU 2 | Hs.61345 | Extracellular defense response | 5.83 | 6 |
DEFα4 | Hs.2582 | Extracellular defense response | 5.81 | 6 |
Interferons-related Genes: | ||||
IFNαR1 | Hs.1513 | JAK-STAT cascade, recptor | 5.41 | 8 |
IRF 7 | Hs.166120 | Transcription regulation | 5.05 | 6 |
IF 144 | Hs.82316 | Invasive growth response | 2.69 | 5 |
IRF 6 | Hs.11801 | Transcription regulation | 2.06 | 14 |
IL 18 | Hs.83077 | Angiogenesis | 1.76 | 6 |
ISGF3γ | Hs.1706 | Regulatory | 1.28 | 9 |
IRF 5 | Hs.334450 | Transcription regulation | 1.23 | 9 |
IFNαR2 | Hs.86958 | Receptor activity | 1.06 | 2 |
IFNγR1 | Hs.180866 | Receptor activity | 0.80 | 5 |
IFNγ | Hs.856 | Growth regulation | 0.53 | 4 |
IRF 3 | Hs.75254 | Transcription regulation | 0.40 | 5 |
IRF 2 | Hs.83795 | Transcription regulation | 0.32 | 4 |
IRF 1 | Hs.80645 | Transcription regulation | 0.30 | 3 |