Figure 2
From: Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003
Non-silent variations in five key ORFs. Nucleotide variations that lie within a coding region might result in amino acid variations in the corresponding protein product. Such non-silent variations could play a significant role in determining the survivability of SARS-CoV variants. Application of the proposed variation filter reveals conservation of the polymerase (RdRp) and 3CLpro, which is consistent with previous studies of other Corona viruses.