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Table 1 Amino acid replacements in polymerase and surface antigen (small S)

From: Hepatitis B virus variants in an HIV-HBV co-infected patient at different periods of antiretroviral treatment with and without lamivudine

Year of collect

Lamivudine

HBV sequences

Polymerase residues

S residues

   

359

473

519

526

550

100

119

164

182

195

216

1999

Yes

Direct

Y

G

V

M

V

C

G

E

W

M

L

  

1-B40

Y

G

V

M

V

C

G

E

W

M

L

  

1-B52

Y

G

V

M

V

C

G

E

W

M

L

  

1-B57

Y

G

L

M

V

C

G

D

W

M

L

2001

No

Direct

Y

E

V

L

M

C

R

E

W

I

L

  

2-B14

Y

E

V

L

M

C

R

E

*

I

L

  

2-B62

Y

E

V

L

M

C

R

E

W

I

*

  

2-B63

Y

E

V

L

M

C

R

E

W

I

L

2002

Yes

Direct

Y

G

L/V

M

V

C

G

D/E

W

M

L

  

3-B02

Y

G

L

M

V

C

G

D

W

M

L

  

3-B06

Y

G

L

M

V

C

G

D

W

M

L

  

3-B71

Y

G

L

M

V

C

G

D

W

M

L

Consensus of genotype A

  

H

G

V

L

M

Y

G

E

W

I

L

  1. Lamivudine resistant mutations in the viral DNA polymerase and their counterparts in the small surface antigen are marked in bold. Asterisks represent stop mutations.
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BMC Infectious Diseases

ISSN: 1471-2334

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