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Table 1 Amino acid replacements in polymerase and surface antigen (small S)

From: Hepatitis B virus variants in an HIV-HBV co-infected patient at different periods of antiretroviral treatment with and without lamivudine

Year of collect Lamivudine HBV sequences Polymerase residues S residues
    359 473 519 526 550 100 119 164 182 195 216
1999 Yes Direct Y G V M V C G E W M L
   1-B40 Y G V M V C G E W M L
   1-B52 Y G V M V C G E W M L
   1-B57 Y G L M V C G D W M L
2001 No Direct Y E V L M C R E W I L
   2-B14 Y E V L M C R E * I L
   2-B62 Y E V L M C R E W I *
   2-B63 Y E V L M C R E W I L
2002 Yes Direct Y G L/V M V C G D/E W M L
   3-B02 Y G L M V C G D W M L
   3-B06 Y G L M V C G D W M L
   3-B71 Y G L M V C G D W M L
Consensus of genotype A    H G V L M Y G E W I L
  1. Lamivudine resistant mutations in the viral DNA polymerase and their counterparts in the small surface antigen are marked in bold. Asterisks represent stop mutations.