TY - JOUR AU - Webley, Wilmore C. AU - Norkin, Leonard C. AU - Stuart, Elizabeth S. PY - 2004 DA - 2004/07/22 TI - Caveolin-2 associates with intracellular chlamydial inclusions independently of caveolin-1 JO - BMC Infectious Diseases SP - 23 VL - 4 IS - 1 AB - Lipid raft domains form in plasma membranes of eukaryotic cells by the tight packing of glycosphingolipids and cholesterol. Caveolae are invaginated structures that form in lipid raft domains when the protein caveolin-1 is expressed. The Chlamydiaceae are obligate intracellular bacterial pathogens that replicate entirely within inclusions that develop from the phagocytic vacuoles in which they enter. We recently found that host cell caveolin-1 is associated with the intracellular vacuoles and inclusions of some chlamydial strains and species, and that entry of those strains depends on intact lipid raft domains. Caveolin-2 is another member of the caveolin family of proteins that is present in caveolae, but of unknown function. SN - 1471-2334 UR - https://doi.org/10.1186/1471-2334-4-23 DO - 10.1186/1471-2334-4-23 ID - Webley2004 ER -