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Table 1 Measurements of the effect of human lysozyme (hLz), lactoferrin (hLf), β defensin-1 (HBD-1) and β defensin-2 (HBD-2) on the growth of otitis media pathogens, using the radial inhibition assay.

From: Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae

   Bacteria
Molecule Total amount of protein/peptide added (in a total volume of 4 μl) NTHi M. catarrhalis S. pneumoniae 3 S. pneumoniae 6B
hLz 50 μg - 4.6 ± 0.4 (P) 6.2 ± 0.7 (C) 6.7 ± 0.9 (C)
  100 μg - 5.6 ± 0.7 (P) 7.2 ± 0.5 (C) 7.4 ± 0.6 (C)
  200 μg - 6.2 ± 0.5 (P) 7.7 ± 0.6 (C) 8.2 ± 0.7 (C)
hLf 4 μg - - - -
  10 μg E - E -
  40 μg E E E E
HBD-1 4 μg - - - -
  10 μg - 7.7 ± 0.6 (P) - -
  40 μg ND ND ND ND
HBD-2 4 μg 9.7 ± 2.5 (C) 11.7 ± 0.6 (C) 8.7 ± 1.5 (C) 8.7 ± 1.2 (C)
  10 μg 12.3 ± 2.9 (C) 14.7 ± 0.6 (C) 10 ± 1.3 (C) 10.7 ± 1.5 (C)
  40 μg ND ND ND ND
  1. Diameter (mm) of the inhibition zone (average of 3 separate experiments ± SD) caused by the different concentrations of the antimicrobial molecules is given in the column below each pathogen. -: No effect; E: Enhanced growth; C: Complete inhibition; P: Partial inhibition; ND: Not done
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