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Table 1 Anti-LASSA Activity of Stampidinc in CBA mice

From: Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus

Disease Onset (Days After Inoculation with Lassa Virus)
  Decreased mobility Scruffy Fur Convulsions Weight Loss (%) Survival (days)
Group A – Vehicle
   Mouse #1* NA NA NA NA ≤ 1
   Mouse #2* NA NA NA NA ≤ 1
   Mouse #3 6.0 6.0 7.0 4.5 8
   Mouse #4 6.0 6.5 8.0 5.0 9
   Mouse #5 7.5 7.0 8.0 9.0 9.5
   Mouse #6 7.5 7.5 8.0 4.3 9.0
   Mouse #7 7.0 7.0 8.0 4.3 9.0
   Mouse #8 7.0 7.0 8.5 4.5 9.5
   Mouse #9 7.0 7.0 8.5 8.3 9.5
   Mouse #10 7.0 7.0 8.5 4.8 9.5
   Mouse #11 8.5 8.0 9.0 5.3 10.5
   Mouse #12 8.5 8.0 9.0 4.5 10.0
   Mouse #13 8.0 8.5 9.5 4.5 10.0
   Mouse #14 9.0 9.0 10.5 4.1 11.0
   Mouse #15 9.0 9.5 11.0 4.3 11.5
   Mouse #16 9.0 10.0 NO NO >21
   Mouse #17 9.0 10.0 NO NO >21
   Mouse #18 9.0 10.0 11.0 NO >21
   Mouse #19 9.0 10.0 NO NO >21
   Mouse #20 9.5 10.0 NO NO >21
Group B – Stampidine 25 mg/kg
   Mouse #1* NA NA NA NA ≤ 1
   Mouse #2* NA NA NA NA ≤ 1
   Mouse #3 6.0 6.0 7.5 4.3 8
   Mouse #4 9.0 9.5 10.0 8.3 9.5
   Mouse #5 9.5 10.0 NO NO >21
   Mouse #6 9.5 10.0 NO NO >21
   Mouse #7 10.0 9.5 NO NO >21
   Mouse #8 9.0 10.0 NO NO >21
   Mouse #9 10.0 10.0 NO NO >21
   Mouse #10 8.5 9.5 NO NO >21
Group C – Stampidine 50 mg/kg
   Mouse #1 13 13 NO 8.7 16
   Mouse #2 9.0 NO NO NO >21
   Mouse #3 9.5 10.0 NO NO >21
   Mouse #4 NO NO NO NO >21
   Mouse #5 NO NO NO NO >21
   Mouse #6 NO NO NO NO >21
   Mouse #7 NO NO NO NO >21
   Mouse #8 NO NO NO NO >21
   Mouse #9 NO NO NO NO >21
   Mouse #10 NO NO NO NO >21
  1. *Mouse died after traumatic intracerebral injection; NA = not applicable; NO = not observed