|
Disease Onset (Days After Inoculation with Lassa Virus)
|
|---|
| |
Decreased mobility
|
Scruffy Fur
|
Convulsions
|
Weight Loss (%)
|
Survival (days)
|
|---|
|
Group A – Vehicle
|
|
Mouse #1*
|
NA
|
NA
|
NA
|
NA
|
≤ 1
|
|
Mouse #2*
|
NA
|
NA
|
NA
|
NA
|
≤ 1
|
|
Mouse #3
|
6.0
|
6.0
|
7.0
|
4.5
|
8
|
|
Mouse #4
|
6.0
|
6.5
|
8.0
|
5.0
|
9
|
|
Mouse #5
|
7.5
|
7.0
|
8.0
|
9.0
|
9.5
|
|
Mouse #6
|
7.5
|
7.5
|
8.0
|
4.3
|
9.0
|
|
Mouse #7
|
7.0
|
7.0
|
8.0
|
4.3
|
9.0
|
|
Mouse #8
|
7.0
|
7.0
|
8.5
|
4.5
|
9.5
|
|
Mouse #9
|
7.0
|
7.0
|
8.5
|
8.3
|
9.5
|
|
Mouse #10
|
7.0
|
7.0
|
8.5
|
4.8
|
9.5
|
|
Mouse #11
|
8.5
|
8.0
|
9.0
|
5.3
|
10.5
|
|
Mouse #12
|
8.5
|
8.0
|
9.0
|
4.5
|
10.0
|
|
Mouse #13
|
8.0
|
8.5
|
9.5
|
4.5
|
10.0
|
|
Mouse #14
|
9.0
|
9.0
|
10.5
|
4.1
|
11.0
|
|
Mouse #15
|
9.0
|
9.5
|
11.0
|
4.3
|
11.5
|
|
Mouse #16
|
9.0
|
10.0
|
NO
|
NO
|
>21
|
|
Mouse #17
|
9.0
|
10.0
|
NO
|
NO
|
>21
|
|
Mouse #18
|
9.0
|
10.0
|
11.0
|
NO
|
>21
|
|
Mouse #19
|
9.0
|
10.0
|
NO
|
NO
|
>21
|
|
Mouse #20
|
9.5
|
10.0
|
NO
|
NO
|
>21
|
|
Group B – Stampidine 25 mg/kg
|
|
Mouse #1*
|
NA
|
NA
|
NA
|
NA
|
≤ 1
|
|
Mouse #2*
|
NA
|
NA
|
NA
|
NA
|
≤ 1
|
|
Mouse #3
|
6.0
|
6.0
|
7.5
|
4.3
|
8
|
|
Mouse #4
|
9.0
|
9.5
|
10.0
|
8.3
|
9.5
|
|
Mouse #5
|
9.5
|
10.0
|
NO
|
NO
|
>21
|
|
Mouse #6
|
9.5
|
10.0
|
NO
|
NO
|
>21
|
|
Mouse #7
|
10.0
|
9.5
|
NO
|
NO
|
>21
|
|
Mouse #8
|
9.0
|
10.0
|
NO
|
NO
|
>21
|
|
Mouse #9
|
10.0
|
10.0
|
NO
|
NO
|
>21
|
|
Mouse #10
|
8.5
|
9.5
|
NO
|
NO
|
>21
|
|
Group C – Stampidine 50 mg/kg
|
|
Mouse #1
|
13
|
13
|
NO
|
8.7
|
16
|
|
Mouse #2
|
9.0
|
NO
|
NO
|
NO
|
>21
|
|
Mouse #3
|
9.5
|
10.0
|
NO
|
NO
|
>21
|
|
Mouse #4
|
NO
|
NO
|
NO
|
NO
|
>21
|
|
Mouse #5
|
NO
|
NO
|
NO
|
NO
|
>21
|
|
Mouse #6
|
NO
|
NO
|
NO
|
NO
|
>21
|
|
Mouse #7
|
NO
|
NO
|
NO
|
NO
|
>21
|
|
Mouse #8
|
NO
|
NO
|
NO
|
NO
|
>21
|
|
Mouse #9
|
NO
|
NO
|
NO
|
NO
|
>21
|
|
Mouse #10
|
NO
|
NO
|
NO
|
NO
|
>21
|
- *Mouse died after traumatic intracerebral injection; NA = not applicable; NO = not observed
