Disease Onset (Days After Inoculation with Lassa Virus) | |||||
---|---|---|---|---|---|
 | Decreased mobility | Scruffy Fur | Convulsions | Weight Loss (%) | Survival (days) |
Group A – Vehicle | |||||
   Mouse #1* | NA | NA | NA | NA | ≤ 1 |
   Mouse #2* | NA | NA | NA | NA | ≤ 1 |
   Mouse #3 | 6.0 | 6.0 | 7.0 | 4.5 | 8 |
   Mouse #4 | 6.0 | 6.5 | 8.0 | 5.0 | 9 |
   Mouse #5 | 7.5 | 7.0 | 8.0 | 9.0 | 9.5 |
   Mouse #6 | 7.5 | 7.5 | 8.0 | 4.3 | 9.0 |
   Mouse #7 | 7.0 | 7.0 | 8.0 | 4.3 | 9.0 |
   Mouse #8 | 7.0 | 7.0 | 8.5 | 4.5 | 9.5 |
   Mouse #9 | 7.0 | 7.0 | 8.5 | 8.3 | 9.5 |
   Mouse #10 | 7.0 | 7.0 | 8.5 | 4.8 | 9.5 |
   Mouse #11 | 8.5 | 8.0 | 9.0 | 5.3 | 10.5 |
   Mouse #12 | 8.5 | 8.0 | 9.0 | 4.5 | 10.0 |
   Mouse #13 | 8.0 | 8.5 | 9.5 | 4.5 | 10.0 |
   Mouse #14 | 9.0 | 9.0 | 10.5 | 4.1 | 11.0 |
   Mouse #15 | 9.0 | 9.5 | 11.0 | 4.3 | 11.5 |
   Mouse #16 | 9.0 | 10.0 | NO | NO | >21 |
   Mouse #17 | 9.0 | 10.0 | NO | NO | >21 |
   Mouse #18 | 9.0 | 10.0 | 11.0 | NO | >21 |
   Mouse #19 | 9.0 | 10.0 | NO | NO | >21 |
   Mouse #20 | 9.5 | 10.0 | NO | NO | >21 |
Group B – Stampidine 25 mg/kg | |||||
   Mouse #1* | NA | NA | NA | NA | ≤ 1 |
   Mouse #2* | NA | NA | NA | NA | ≤ 1 |
   Mouse #3 | 6.0 | 6.0 | 7.5 | 4.3 | 8 |
   Mouse #4 | 9.0 | 9.5 | 10.0 | 8.3 | 9.5 |
   Mouse #5 | 9.5 | 10.0 | NO | NO | >21 |
   Mouse #6 | 9.5 | 10.0 | NO | NO | >21 |
   Mouse #7 | 10.0 | 9.5 | NO | NO | >21 |
   Mouse #8 | 9.0 | 10.0 | NO | NO | >21 |
   Mouse #9 | 10.0 | 10.0 | NO | NO | >21 |
   Mouse #10 | 8.5 | 9.5 | NO | NO | >21 |
Group C – Stampidine 50 mg/kg | |||||
   Mouse #1 | 13 | 13 | NO | 8.7 | 16 |
   Mouse #2 | 9.0 | NO | NO | NO | >21 |
   Mouse #3 | 9.5 | 10.0 | NO | NO | >21 |
   Mouse #4 | NO | NO | NO | NO | >21 |
   Mouse #5 | NO | NO | NO | NO | >21 |
   Mouse #6 | NO | NO | NO | NO | >21 |
   Mouse #7 | NO | NO | NO | NO | >21 |
   Mouse #8 | NO | NO | NO | NO | >21 |
   Mouse #9 | NO | NO | NO | NO | >21 |
   Mouse #10 | NO | NO | NO | NO | >21 |