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Table 5 Inhibition of virus yield after removal of tetrapyrroles before cell lysis.a

From: Prevention of poxvirus infection by tetrapyrroles

Compound Concentration
  25 µg/mL 50 µg/mL
  titer (pfu/mL) % inhibition titer (pfu/mL) % inhibition
TNapPS 3.5 × 105 73 ± 16 1.0 × 105 92 ± 1
TAnthPS 1.2 × 106 39 ± 13 7.5 × 105 67 ± 15
CuHPIX 1.3 × 106 33 ± 9 6.3 × 105 71 ± 4
CuPcS(3444) 9.3 × 105 49 ± 21 8.3 × 105 59 ± 2
ZnPPIX 7.2 × 105 65 ± 0.3 6.4 × 105 70 ± 4
  1. aCV-1 cells were infected at 2.5 pfu/cell and then treated with compounds at 50 or 25 µg/mL; at 16 h post-infection, the medium was removed and cells were washed and harvested for virus titration by plaque assay. Virus titer in the control was 2.1 × 106 pfu/mL. Data are expressed as means ± std of triplicate experiments, each replicated twice. % inhibition was calculated as described in Table 4.