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Table 5 Inhibition of virus yield after removal of tetrapyrroles before cell lysis.a

From: Prevention of poxvirus infection by tetrapyrroles

Compound

Concentration

 

25 µg/mL

50 µg/mL

 

titer (pfu/mL)

% inhibition

titer (pfu/mL)

% inhibition

TNapPS

3.5 × 105

73 ± 16

1.0 × 105

92 ± 1

TAnthPS

1.2 × 106

39 ± 13

7.5 × 105

67 ± 15

CuHPIX

1.3 × 106

33 ± 9

6.3 × 105

71 ± 4

CuPcS(3444)

9.3 × 105

49 ± 21

8.3 × 105

59 ± 2

ZnPPIX

7.2 × 105

65 ± 0.3

6.4 × 105

70 ± 4

  1. aCV-1 cells were infected at 2.5 pfu/cell and then treated with compounds at 50 or 25 µg/mL; at 16 h post-infection, the medium was removed and cells were washed and harvested for virus titration by plaque assay. Virus titer in the control was 2.1 × 106 pfu/mL. Data are expressed as means ± std of triplicate experiments, each replicated twice. % inhibition was calculated as described in Table 4.
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BMC Infectious Diseases

ISSN: 1471-2334

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