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Table 4 Reduction of vaccinia virus yield by selected tetrapyrroles.a

From: Prevention of poxvirus infection by tetrapyrroles

Compound Concentration
  25 µg/mL 50 µg/mL
  titer (pfu/mL) % inhibition titer (pfu/mL) % inhibition
TNapPS 3.5 × 105 98 2.6 × 105 98
TAnthPS 3.0 × 106 81 5.8 × 105 96
CuHPIX 1.1 × 106 93 4.5 × 105 97
CuPcS(3444) 6.3 × 106 60 4.1 × 106 74
ZnPPIX 2.5 × 105 98 1.0 × 105 99
  1. aCV-1 cells were infected with the WR strain at 2.5 pfu/cell and then media containing compounds at 50 or 25 µg/mL were added; at 16 h post-infection, the cells and media were collected for virus titration by plaque assay. % inhibition = (1 - TA/TB) × 100 where TA is the average virus titer in the presence of the tetrapyrrole and TB is the virus titer where no compound was added (control). Virus titer in the control was 1.6 × 107 pfu/mL. Data are means of duplicate experiments.