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Table 2 Therapeutic indices of selected tetrapyrroles.

From: Prevention of poxvirus infection by tetrapyrroles

Compound   Therapeutic index
  CC50 (µg/mL)a WR IHD-J IHD-J (EEV)
ZnPPIX 50 3 2 1
CuPcS(3444) 2000 70 140 240
TNapPS4 500 600 700 500
TAnthPS4 50 170 1000 250
TPP[2,6-(OH)2] 50 290 85 71
CuHPIX 500 64 330 460
Co(III)TPP(2,6-F2)S 500 310 1100 82
TPP4OMeS 300 300 230 600
TPP2ClS 1000 1000 1000 1400
TPP2FS 200 150 770 180
  1. aCV-1 cell viability was determined by trypan blue assay as described in Materials and Methods.