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Table 1 Prevention of vaccinia virus infection by tetrapyrroles.

From: Prevention of poxvirus infection by tetrapyrroles

Compound

EC50 (µg/ml)

 

WR

IHD-J

IHD-J (EEV)

 

CV-1

BSC-40

CV-1

CV-1

BSC-40

ZnPPIX

15 ± 12

 

26 ± 3.4

38 ± 7.8

 

CuPcS(3444)

29 ± 13

>50

14 ± 5.3

8.2 ± 1.3

50 ± 7

TNapPS

0.83 ± 0.1

 

0.71 ± 0.3

1.0 ± 0.1

 

TAnthPS

0.30 ± 0.1

0.15 ± 0.03

0.05 ± 0.0005

0.2 ± 0.1

0.55 ± 0.14

TPP[2,6-(OH)2]

0.17 ± 0.01

0.19 ± 0.03

0.59 ± 0.1

0.7 ± 0.2

0.32 ± 0.11

CuHPIX

7.8 ± 0.9

0.03 ± 0.01

1.5 ± 0.4

1.1 ± 0.4

0.32 ± 0.13

Co(III)TPP(2,6-F2)S

1.6 ± 0.1

0.74 ± 0.38

0.44 ± 0.02

6.1 ± 1.6

5.6 ± 2.8

TPP4OMeS

1.0 ± 0.1

 

1.3 ± 0.4

0.5 ± 0.1

 

TPP2ClS

1.0 ± 0.2

 

1.0 ± 0.1

0.7 ± 0.1

 

TPP2FS

1.3 ± 0.3

 

0.26 ± 0.1

1.1 ± 0.5