TY - JOUR AU - Sharma, M. Kaushal AU - Al-Azem, A. AU - Wolfe, J. AU - Hershfield, E. AU - Kabani, A. PY - 2003 DA - 2003/04/08 TI - Identification of a predominant isolate of Mycobacterium tuberculosis using molecular and clinical epidemiology tools and in vitrocytokine responses JO - BMC Infectious Diseases SP - 3 VL - 3 IS - 1 AB - Tuberculosis (TB) surveillance programs in Canada have established that TB in Canada is becoming a disease of geographically and demographically distinct groups. In 1995, treaty status aboriginals from the province of Manitoba accounted for 46% of the disease burden of this sub-group in Canada. The TB incidence rates are dramatically high in certain reserves of Manitoba and are equivalent to rates in African countries. The objective of our study was to identify prevalent isolates of Mycobacterium tuberculosis in the patient population of Manitoba using molecular epidemiology tools, studying the patient demographics associated with the prevalent strain and studying the in vitro cytokine profiles post-infection with the predominant strain. SN - 1471-2334 UR - https://doi.org/10.1186/1471-2334-3-3 DO - 10.1186/1471-2334-3-3 ID - Sharma2003 ER -