Figure 1

Schematic represention of the eSensor DNA Detection System. A self-assembled monolayer is generated on a gold electrode. For electrochemical detection to occur across the monolayer, two hybridization events must occur: the first between the capture probe (shown in black perpendicular to the electrode) and the target (for example, HPV DNA, shown in gray), and the second between an adjacent region of the target and ferrocene labeled signal probe (shown in black parallel to the monolayer).