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Table 1 Percent of ACVr mutants from tk mutagenesis assaya.

From: Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations

 

%ACVr

Virusb

3 μg/ml

8 μg/ml

HSV-2 SB5

0.8

0.7

HSV-2 SB5PR

0.06

0.04

HSV-2 6652

1.0

0.8

HSV-2 6652PR

0.04

0.01

HSV-2 83D

0.7

0.5

HSV-2 83D PR

0.18

0.06

HSV-2 6757

28

20

HSV-2 6757PR

5.0

3.0

HSV-1 SC16

0.06

0.05

PAAr5

0.001

0.0006

  1. a The proportion of resistant virus was calculated as follows: (titer in the presence of drug) / (titer in the absence of drug) × 100. b Virus labeled PR represents pol-recombinant virus.