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Table 1 Percent of ACVr mutants from tk mutagenesis assaya.

From: Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations

  %ACVr
Virusb 3 μg/ml 8 μg/ml
HSV-2 SB5 0.8 0.7
HSV-2 SB5PR 0.06 0.04
HSV-2 6652 1.0 0.8
HSV-2 6652PR 0.04 0.01
HSV-2 83D 0.7 0.5
HSV-2 83D PR 0.18 0.06
HSV-2 6757 28 20
HSV-2 6757PR 5.0 3.0
HSV-1 SC16 0.06 0.05
PAAr5 0.001 0.0006
  1. a The proportion of resistant virus was calculated as follows: (titer in the presence of drug) / (titer in the absence of drug) × 100. b Virus labeled PR represents pol-recombinant virus.