TY - JOUR AU - Polymenidou, Magdalini AU - Verghese-Nikolakaki, Susan AU - Groschup, Martin AU - Chaplin, Melanie J. AU - Stack, Mick J. AU - Plaitakis, Andreas AU - Sklaviadis, Theodoros PY - 2002 DA - 2002/10/08 TI - A short purification process for quantitative isolation of PrPScfrom naturally occurring and experimental transmissible spongiform encephalopathies JO - BMC Infectious Diseases SP - 23 VL - 2 IS - 1 AB - Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases affecting both humans and animals. They are associated with post-translational conversion of the normal cellular prion protein (PrPC) into a heat- and protease-resistant abnormal isoform (PrPSc). Detection of PrPSc in individuals is widely utilized for the diagnosis of prion diseases. SN - 1471-2334 UR - https://doi.org/10.1186/1471-2334-2-23 DO - 10.1186/1471-2334-2-23 ID - Polymenidou2002 ER -