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Table 2 Description of studies and the associated cure rates

From: Shorter courses of parenteral antibiotic therapy do not appear to influence response rates for children with acute hematogenous osteomyelitis: a systematic review

Author

Publication year

Sample size1

S. aureus positive culture (%)

Parenteral (IV) antimicrobial

Days of IV

treatment Mean

(range)

Oral

antimicrobial

Days of oral

treatment Mean

(range)

Cure rate % (CI)

Long Course

Kolyvas2

1980

5

50.03

Cephradine +/-

Ampicillin

28 (28–28)

Cephradine or

Cloxacillin

18 (14–35)

100

(67, 100)

Tetzlaff

1978

18

100.0

Methicillin or

Cefazolin

8 (7–13)

Cephalexin or

Penicillin V

20 (13–42)

94

(77, 100)

Bryson

1979

18

100.0

Oxacillin or

Methicillin

7 (5–14)

Dicloxacillin

N/A (28–56)

100

(89, 100)

Rodriguez

1977

21

90.5

Clindamycin4

25 (21–28)

Clindamycin

42 (42–42)

100

(91, 100)

Prober

1979

22

100.0

Nafcillin or

Methicillin

145 (4–28)

Dicloxacillin

283 (N/A)

100

(91, 100)

Short Course

Kolyvas2

1980

5

50.03

 

3 (N/A)

Cephradine or

Cloxacillin

423 (39–60)3

100

(67, 100)

Refass6

1989

6

98.9

Cloxacillin

N/A (5–6)

Flucloxacillin

N/A (7–200)3

100

(72, 100)

Freij

1987

8

100.0

Imipenem +

Cilastatin

5.5 (4–9)

Cefaclor or

Dicloxacillin or Cephalexin or

Bacampicillin or Penicillin V

15 (13–19)

88

(55, 100)

Feigin7

1975

11

72.7

Clindamycin

6 (3–13)

Clindamycin

425 (N/A)

91

(65, 100)

Geddes8

1977

18

65.03

Clindamycin

63 (N/A)

Clindamycin

903 (N/A)

94

(77, 100)

Cole9

1982

48

94.5

Cloxacillin or

Cephalothin

3 (2–5)

Cloxacillin or

Cephalexin

39 (37–40)

92

(81, 97)

Peltola

1997

50

100.0

Cephradine or

Cephalothin or

Clindamycin

4 (4–6)

Cefadroxil or

Clindamycin

19 (17–19)

100

(96, 100)

  1. 1 Includes cases that were due to Staphylococcus aureus and those who were culture negative 2 Included only the cases that had osteomyelitis alone or had contiguous arthritis and osteomyelitis. 3 Estimated value. 4 Clindamycin is the only macrolide studied – all other antimicrobials mentioned are beta-lactams. 5 Median reported. 6 Only the 6 patients who clearly met the diagnostic criteria were included. 7 Data abstracted from the 11 cases of osteomyelitis (8 of whom had S. aureus). 8 Only data for the 18 children with acute osteomyelitis from the study were included. Some of these may only have received oral medication. 9 Data from the 48 patients for whom there was follow-up of greater than 6 months.