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Table 1 Descriptive analysis of baseline clinical and therapeutical variables: monoinfected vs coinfected patients.

From: Sustained virological response to peginterferon therapy in patients infected with HCV (genotypes 2 and 3), with or without HIV

Variables

HIV- (n = 385)

HIV+ (n = 76)

OR (95% IC)

p-value

Cirrhosis, % (n)

6% (23/385)

31.6 % (24/76)

7.2 (3.7-13.8)

<0.0001

HCV-RNA >500.000 IU/ml, % (n)

50.1% (191/381)

35.5 % (27/76)

0.5 (0.3-0.9)

0.02

PegIFN alfa-2b vs alfa-2a, % (n)

15.5% (61/385)

30.3 % (23/76)

2.34 (1.3-4.1)

0.002

PegIFN reduction, % (n)

11.7% (45/385)

5.3 % (4/76)

0.4 (0.1-1.1)

0.09

Stop PegIFN, % (n)

14% (54/385)

30.3 % (23/76)

2.6 (1.5-4.6)

0.0005

RBV reduction, % (n)

14.5% (56/385)

14.5 % (11/76)

0.9 (0.4-1.9)

0.987

Stop RBV, % (n)

9.6% (37/385)

27.6 % (21/76)

3.5 (1.9-6.5)

<0.0001

Age >45 years, % (n)

51.9% (200/385)

50% (38/76)

0.92 (0.5-1.5)

0.76

Male gender, % (n)

63.4% (244/385)

82.9 % (63/76)

2.8 (1.5-5.4)

0.009

Genotype 3, % (n)

47% (181/385)

94.7 % (72/76)

20.2 (7.8-66.2)

<0.0001

PLT <130,000 cell/mm3, % (n)

7.5% (29/385)

32.9 % (25/76)

6 (3.2-11)

<0.0001

HIV RNA <50 cp/ml, % (n)

 

90.8% (69/76)

  

Patients in HAART, % (n)

 

98.7% (75/76)

  

Variables

HIV- (n = 385)

HIV+ (n = 76)

 

p -value

ALT, IU/l, mean (DS)

117.6 (111.4)

114.6 (74.7)

 

0.2126

AST, IU/l, mean (DS)

69.2 (66.3)

74.8 (49.1)

 

0.0123

BMI, mean (DS)

25.2 (4.2)

23.7 (3.1)

 

0.006

Cholesterol, mg/dl, mean (DS)

175 (42.7)

150.5 (40)

 

<0.0001

Triglycerids, mg/dl, mean (DS)

88.8 (43.8)

112.3 (63)

 

0.001

Age, years, mean (DS)

46.1 (12.3)

44 (5.5)

 

0.33

Glycemia, mean (DS)

94.4 (19.1)

90.8 (12.2)

 

0.082

Hb, g/dl, mean (DS)

14.9 (1.5)

14.5 (2.1)

 

0.095

PT, mean (DS)

103.6 (11.4)

100.5 (13.4)

 

0.12

Neutrophils, cell/mm3, mean (DS)

3400 (1231)

3080 (1342)

 

0.014

Weeks of treatment, mean (DS)

19 (8)

41 (17)

 

<0.0001

Bilirubin, mg/dl, mean (DS)

0.7 (0.4)

1.5 (1.4)

 

<0.0001

Albumin, g/dl, mean (DS)

4.5 (2.2)

4.4 (0.4)

 

0.896

CD4+ cell count (cell/mm3), mean (DS)

 

489 (273)

  

Nadir CD4 (cell/mm3), mean (DS)

 

213 (158)

  
  1. PLT, platelets; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, Body Mass Index; Hb, hemoglobin; PT, prothrombin time.