TST | QFN-G-IT | T-SPOT.TB | ||
---|---|---|---|---|
Sensitivity | Low income countries |
0.67 (95%CI 0.64-0.70); Chi-square = 261.59; df = 15 (p =0.0000) Inconsistency (I-square)= 94.3% |
0.57 (95%CI 0.52-0.61); Chi-square = 51.04; df = 10 (p =0.0000) Inconsistency (I-square)= 80.4% |
0.61 (95%CI 0.57-0.65); Chi-square = 71.42; df = 4 (p =0.0000) Inconsistency (I-square)= 94.4% |
High income countries |
0.78 (95%CI 0.74-0.82); Chi-square = 69.96; df = 17 (p =0.0000) Inconsistency (I-square)= 79.3% |
0.79 (95%CI 0.75-0.82); Chi-square = 77.27; df = 19 (p =0.0000) Inconsistency (I^{2}) = 75.4% |
0.67 (95%CI 0.62-0.73); Chi-square = 44.79; df = 8 (p =0.0000) Inconsistency (I-square)= 82.1% | |
Including only studies using the three assays simoultaneously |
0.85 (95%CI 0.78-0.91); Chi-square = 26.01; df = 5 (p =0.0001) Inconsistency (I-square)= 80.8% |
0.78 (95%CI 0.70-0.84); Chi-square = 16.85; df = 5 (p =0.0048) Inconsistency (I-square)= 70.3% |
0.76 (95%CI 0.68-0.83); Chi-square = 24.94; df = 6 (p =0.0001) Inconsistency (I-square)= 80.0% | |
Including microbiologically confirmed cases (overall) |
0.79 (95%CI 0.75-0.83); Chi-square = 41.56; df = 16 (p =0.0005) Inconsistency (I-square)= 61.5% |
0.81 (95%CI 0.76-0.85); Chi-square = 45.51; df = 15 (p =0.0001) Inconsistency (I-square)= 67.0% |
0.80 (95%CI 0.73-0.86); Chi-square = 27.31; df = 8 (p =0.0006) Inconsistency (I-square)= 70.7% | |
Including microbiologically confirmed cases, in low income countries |
0.74 (95%CI 0.68-0.80); Chi-square = 20.28; df = 6 (p =0.0025) Inconsistency (I-square)= 70.4% |
0.66 (95%CI 0.55-0.76); Chi-square = 6.19; df = 4 (p =0.1857) Inconsistency (I-square)= 35.3% - excluding studies with immunocompromised children: 0.68 (95%IC 0.57-0.79); Chi-square = 3.18; df = 3 (p =0.3644) Inconsistency (I-square)= 5.7% |
0.80 (95%CI 0.59-0.90); Chi-square = 17.35; df = 4 (p =0.0017) Inconsistency (I-square)= 76.9% | |
Including microbiologically confirmed cases, in high income countries |
0.86 (0.79-0.91); Chi-square = 14.06; df = 9 (p =0.1203) Inconsistency (I-square)= 36.0% |
0.86 (0.81-0.90); Chi-square = 25.78; df = 10 (p =0.0040) Inconsistency (I-square)= 61.2% |
0.79 (0.69-0.87); Chi-square = 9.90; df = 3 (p =0.0194) Inconsistency (I-square)= 69.7% | |
Immunocompromised/HIV infected children |
0.54 (95%IC 0.49-0.59); Chi-square = 71.45; df = 3 (p =0.0000) Inconsistency (I-square)= 95.8% |
0.47 (95%CI 0.38-0.55); Chi-square = 37.77; df = 2 (p =0.0000) Inconsistency (I-square)= 94.7% | Not evaluable | |
Specificity | Low income countries |
0.90 (95%IC 0.87-0.92); Chi-square = 38.57; df = 7 (p =0.0000) Inconsistency (I-square)= 81.9% |
0.85 (95%CI 0.82-0.88); Chi-square = 19.15; df = 5 (p =0.0018) Inconsistency (I-square)= 73.9% |
0.93 (95%CI 0.87-0.96); Chi-square = 7.75; df = 2 (p =0.0207) Inconsistency (I-square)= 74.2% |
High income countries |
0.92 (95%CI 0.89-0.93); Chi-square = 125.84; df = 10 (p =0.0000) Inconsistency (I-square)= 92.8% |
0.97 (95%CI 0.96-0.98); Chi-square = 38.83; df = 10 (p =0.0000) Inconsistency (I-square)= 74.2% |
0.98 (95%CI 0.96-0.99); Chi-square = 12.98; df = 5 (p =0.0235) Inconsistency (I-square)= 61.5% | |
Including only studies using the three assays simoultaneously (all in high income countries) |
0.84 (95%CI 0.79-0.89); Chi-square = 74.74; df = 4 (p =0.0000) Inconsistency (I-square)= 94.6% |
0.97 (95% CI 0.93-0.99); Chi-square = 6.05; df = 3 (p =0.1093) Inconsistency (I-square)= 50.4% |
0.97 (95%CI 0.93-0.99); Chi-square = 8.47; df = 3 (p =0.0373) Inconsistency (I-square)= 64.6% | |
Immunocompromised/HIV infected children |
0.97 (0.92-0.99); Chi-square = 0.95; df = 1 (p =0.0000) Inconsistency (I-square)= 0.0% Chi-square = 0.95; df = 1 (p =0.0000) Inconsistency (I-square)= 0.0% |
0.90 (95%CI 0.81-0.95); Chi-square = 0.00; df = 1 (p =0.9695) Inconsistency (I-square)= 0.0% - only 2 studies could be included - | Not evaluable |