Table 1 Sensitivity and specificity of Interferon-gamma release assays (IGRAs) and tuberculin skin test (TST) in the previous published meta-analyses [1, 5–12]
| Â | TST | QFN-G-IT | T-SPOT.TB | Population | Number of studies considered | Author, year of publication |
|---|---|---|---|---|---|---|
Sensitivity | 0.70 (95%CI 0.67-0.72) | 0.81 (95%CI 0.78-0.89) | 0.84 (95%CI 0.81-0.87) | Adults | 124 | Diel, 2010 |
| Â | 0.77 (95%CI 0.71-0.82) | 0.78 (95% CI 73-82) | 0.90 (95%CI 0.86-0.93) | Adults | 20 | Pai, 2008 |
| Â | Â | 0.80 (95%CI 0.75-0.91) | 0.81 (95CI 0.78-0.84) | Adults | 27 | Sester, 2010 |
| Â | 0.80 (95%CI 0.70-0.90) | 0.83(95%CI 0.75-0.92) | 0.84(95%CI 0.63-1.00) | Children | 32 | Mandalakas, 2011 |
| Â | 0.71(95%CI 0.67-0.75) | 0.70 (95%CI 0.65-0.75) | 0.62 (95%CI 0.57-0.67) | Children | 16 | Sun, 2011 |
| Â | 0.82(95%CI 0.72-0.93) | 0.79 (95%CI 0.70-0.89) | 0.74 (95%CI 0.59-0.90) | Children | 11 | Chiappini, 2012 |
| Â | Â | 0.77 (95%CI 0.64-0.73) | Â | Adults and Children | 11 | Dheda, 2009 |
| Â | Â | 0.66 (95%IC 0.53-0.78) | Â | Children | 6 | Machingaidze, 2011 |
| Â | 0.71 (95%CI 0.65-0.74) | 0.76 (95%CI 0.70-0.83) | 0.88 (95%CI 0.81-0.95) | Adults and Children | 58 | Menzies, 2007 |
Specificity | Â | 0.99 (95%CI 0.98-1.00) | 0.86 (95%CI 0.81-0.90) | Adults | 124 | Diel, 2010 |
| Â | 0.59 (95%CI 0.46-0.73) | 0.96 (95%CI 94-98) | 0.93 (95%CI 0.86-1.00) | Adults | 20 | Pai, 2008 |
| Â | Â | 0.82 (95%CI 0.70-0.91) | 0.82 (95%CI 0.78-0.86) | Adults | 27 | Sester, 2010 |
| Â | 0.85 (95%CI 0.69-1.00) | 0.91 (95% CI 0.78-1.00) | 0.94 (95%CI 0.87-1.00) | Children | 32 | Mandalakas, 2011 |
| Â | 0.56 (95% CI 0.50-0.61) | 1.00 (95%CI 0.84-1.00) | 0.90 (95%CI 0.86-0.93) | Children | 16 | Sun, 2011 |
| Â | 0.83 (95%CI 0.74-0.92) | 0.95 (95%CI 0.93-0.97) | 0.96 (95%CI 0.95-1.00) | Children | 8 | Chiappini, 2012 |
| Â | 0.66 (95%CI 0.46-0.86) | 0.97 (95%CI 0.96-0.99) | 0.92 (95%CI 0.86-0.99) | Adults and Children | 58 | Menzies, 2007 |