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Table 1 Sensitivity and specificity of Interferon-gamma release assays (IGRAs) and tuberculin skin test (TST) in the previous published meta-analyses [1, 512]

From: Systematic review and meta-analysis on the utility of Interferon-gamma release assays for the diagnosis of Mycobacterium tuberculosis finfection in children: a 2013 update

  TST QFN-G-IT T-SPOT.TB Population Number of studies considered Author, year of publication
Sensitivity 0.70 (95%CI 0.67-0.72) 0.81 (95%CI 0.78-0.89) 0.84 (95%CI 0.81-0.87) Adults 124 Diel, 2010
  0.77 (95%CI 0.71-0.82) 0.78 (95% CI 73-82) 0.90 (95%CI 0.86-0.93) Adults 20 Pai, 2008
   0.80 (95%CI 0.75-0.91) 0.81 (95CI 0.78-0.84) Adults 27 Sester, 2010
  0.80 (95%CI 0.70-0.90) 0.83(95%CI 0.75-0.92) 0.84(95%CI 0.63-1.00) Children 32 Mandalakas, 2011
  0.71(95%CI 0.67-0.75) 0.70 (95%CI 0.65-0.75) 0.62 (95%CI 0.57-0.67) Children 16 Sun, 2011
  0.82(95%CI 0.72-0.93) 0.79 (95%CI 0.70-0.89) 0.74 (95%CI 0.59-0.90) Children 11 Chiappini, 2012
   0.77 (95%CI 0.64-0.73)   Adults and Children 11 Dheda, 2009
   0.66 (95%IC 0.53-0.78)   Children 6 Machingaidze, 2011
  0.71 (95%CI 0.65-0.74) 0.76 (95%CI 0.70-0.83) 0.88 (95%CI 0.81-0.95) Adults and Children 58 Menzies, 2007
Specificity   0.99 (95%CI 0.98-1.00) 0.86 (95%CI 0.81-0.90) Adults 124 Diel, 2010
  0.59 (95%CI 0.46-0.73) 0.96 (95%CI 94-98) 0.93 (95%CI 0.86-1.00) Adults 20 Pai, 2008
   0.82 (95%CI 0.70-0.91) 0.82 (95%CI 0.78-0.86) Adults 27 Sester, 2010
  0.85 (95%CI 0.69-1.00) 0.91 (95% CI 0.78-1.00) 0.94 (95%CI 0.87-1.00) Children 32 Mandalakas, 2011
  0.56 (95% CI 0.50-0.61) 1.00 (95%CI 0.84-1.00) 0.90 (95%CI 0.86-0.93) Children 16 Sun, 2011
  0.83 (95%CI 0.74-0.92) 0.95 (95%CI 0.93-0.97) 0.96 (95%CI 0.95-1.00) Children 8 Chiappini, 2012
  0.66 (95%CI 0.46-0.86) 0.97 (95%CI 0.96-0.99) 0.92 (95%CI 0.86-0.99) Adults and Children 58 Menzies, 2007
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