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Table 4 Doses of first- and second-line anti-tubercular drugs recommended in adults and in children [30, 93, 98, 111].qd= ones a day; bid= twice a day; tid= three times a day.

From: Clinical peculiarities of tuberculosis

Anti-tubercular drugs Dosages in adults (mg/kg) Dosages in children (mg/kg)
First-line anti-tubercular drugs   
Isoniazid 4–6qd 10–15 qd
Rifampicin 8–12 qd 10–20 qd
Pyrazinamide 20–30 qd 30–40 qd
Ethambutol 15–20 qd 15–25 qd
Second-line anti-tubercular drugs Dosages in adults (mg/kg) Dosages in children (mg/kg)
Capreomycin 15-30 qd 15-30 qd
Kanamycin 15-30 qd 15-30 qd
Amikacin 15-20 qd 15-30 qd
Streptomycin 12-18 qd 20-40 qd
Levofloxacin 7,5-10 qd 7,5-10 qd in children aged ˃ 5 bid in children aged ˂ 5
Moxifloxacin 7,5-10qd 7,5-10 qd
Ofloxacin 15-20qd 15-20 qd
Ethionamide 15-20 qd 15-20 qd
Protionamide 15-20 qd 15-20 qd
Cycloserine 15-20 qd 10-20 qd
Para-amino-salicylic acid (PAS) 150 qd 200-300 qd
Anti-TB drugs with unclear efficacy Dosages in adults (mg) Dosages in children (mg/kg)
Linezolid 600 qd 10 qd
Clarithromycin 500 bid 7,5 bid
Clofazimine 200qd 1 mg/kg qd
Meropenem 2000 tid 20-40 tid
Amoxicillin/clavulanate 2000/250 bid (maximum dosage)* 40 bid (based on amoxicillin component)*
  1. * Recommended dosage of amoxicillin/clavulanate in adults and children is not clear because of the amoxicillin to clavulanate ratio in commercially available tables and oral suspensions goes from 2:1 to 7:1.