Clinical peculiarities of tuberculosis

Table 4 Doses of first- and second-line anti-tubercular drugs recommended in adults and in children [30, 93, 98, 111].qd= ones a day; bid= twice a day; tid= three times a day.

Anti-tubercular drugs	Dosages in adults (mg/kg)	Dosages in children (mg/kg)
First-line anti-tubercular drugs
Isoniazid	4–6qd	10–15 qd
Rifampicin	8–12 qd	10–20 qd
Pyrazinamide	20–30 qd	30–40 qd
Ethambutol	15–20 qd	15–25 qd
Second-line anti-tubercular drugs	Dosages in adults (mg/kg)	Dosages in children (mg/kg)
Capreomycin	15-30 qd	15-30 qd
Kanamycin	15-30 qd	15-30 qd
Amikacin	15-20 qd	15-30 qd
Streptomycin	12-18 qd	20-40 qd
Levofloxacin	7,5-10 qd	7,5-10 qd in children aged ˃ 5 bid in children aged ˂ 5
Moxifloxacin	7,5-10qd	7,5-10 qd
Ofloxacin	15-20qd	15-20 qd
Ethionamide	15-20 qd	15-20 qd
Protionamide	15-20 qd	15-20 qd
Cycloserine	15-20 qd	10-20 qd
Para-amino-salicylic acid (PAS)	150 qd	200-300 qd
Anti-TB drugs with unclear efficacy	Dosages in adults (mg)	Dosages in children (mg/kg)
Linezolid	600 qd	10 qd
Clarithromycin	500 bid	7,5 bid
Clofazimine	200qd	1 mg/kg qd
Meropenem	2000 tid	20-40 tid
Amoxicillin/clavulanate	2000/250 bid (maximum dosage)*	40 bid (based on amoxicillin component)*

* Recommended dosage of amoxicillin/clavulanate in adults and children is not clear because of the amoxicillin to clavulanate ratio in commercially available tables and oral suspensions goes from 2:1 to 7:1.