Table 3 First-line drugs used for treatment of tuberculosis in childhood [1, 9, 12, 13, 24, 27–31]
From: Tuberculosis in childhood: a systematic review of national and international guidelines
Daily dosage (maximum dosage) | Twice-thrice weekly dosage (maximum dosage) | Adverse Reactions | |
|---|---|---|---|
Isoniazid (INH) | 10-15 mg/kg (300 mg) | 20-30 mg/kg (900 mg) | Hepatotoxic effects , such as mild hepatic enzyme elevation and hepatitis, gastritis, peripheral neuropathy, hypersensitivity |
Rifampicin (RIF) | 10-20 mg/kg (600 mg) | 10-20 mg/kg (600 mg) | Orange discoloration of secretions and urine, vomiting, hepatitis, influenza-like reaction, thrombocytopenia |
Pyrazinemide (PZA) | 30-40 mg/kg (2 g) | 50 mg/kg (2 g) | Hepatotoxic effects, hyperuricemia, arthralgia, gastrointestinal tract disturbances |
Ethambutol (EMB) | 15-25 mg/kg (2,5 g) | 50 mg/kg (2,5 g) | Optic neuritis with decreased red-green colour discrimination and visual acuity, gastrointestinal disturbances, hypersensitivity |