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Table 2 Incidence of HPV by male circumcision status

From: Male circumcision and the incidence and clearance of genital human papillomavirus (HPV) infection in men: the HPV Infection in men (HIM) cohort study

HPV Type Uncircumcised men Circumcised men Log-rank test p HR (95% CI) [circumcised versus uncircumcised]
No. Infections/No. PYs Incidence per 100 PYs (95% CI) % 12-month Incidence (95% CI) No. Infections/No. PYs Incidence per 100 PYs (95% CI) % 12-month Incidence (95% CI)
Any HPV a 555/1098 50.5 (46.4, 54.9) 38.7 (35.5, 41.7) 359/788 45.6 (41, 50.5) 35.2 (31.4, 38.8) 0.29 0.93 (0.81-1.06)
Oncogenic b 584/2055 28.4 (26.2, 30.8) 23.7 (21.5, 25.9) 369/1285 28.7 (25.9, 31.8) 23.3 (20.5, 26) 0.64 1.03 (0.84-1.26)
16 204/3546 5.8 (5, 6.6) 5.1 (4.1, 6) 143/2164 6.6 (5.6, 7.8) 6.3 (4.9, 7.7) 0.15 1.17 (0.95-1.45)
18 97/3886 2.5 (2, 3) 1.9 (1.3, 2.5) 71/2421 2.9 (2.3, 3.7) 3.1 (2.1, 4) 0.24 1.20 (0.88-1.63)
31 71/3904 1.8 (1.4, 2.3) 1.6 (1.1, 2.2) 52/2462 2.1 (1.6, 2.8) 2 (1.2, 2.8) 0.40 1.17 (0.81-1.67)
33 24/4039 0.6 (0.4, 0.9) 0.4 (0.1, 0.6) 16/2532 0.6 (0.4, 1) 0.8 (0.3, 1.2) 0.86 1.06 (0.56-2.00)
35 44/3951 1.1 (0.8, 1.5) 0.8 (0.5, 1.2) 26/2492 1 (0.7, 1.5) 1 (0.5, 1.6) 0.83 0.95 (0.58-1.55)
39 106/3800 2.8 (2.3, 3.4) 2.6 (1.9, 3.3) 95/2358 4 (3.3, 4.9) 3.4 (2.3, 4.4) 0.01 1.47 (1.11-1.94)
45 94/3876 2.4 (2, 3) 1.8 (1.2, 2.4) 62/2451 2.5 (1.9, 3.2) 2.9 (1.9, 3.8) 0.70 1.06 (0.77-1.47)
51 187/3615 5.2 (4.5, 6) 4.5 (3.6, 5.5) 142/2160 6.6 (5.5, 7.7) 6.8 (5.4, 8.3) 0.02 1.30 (1.04-1.61)
52 164/3525 4.7 (4, 5.4) 5.4 (4.4, 6.4) 98/2277 4.3 (3.5, 5.2) 4.3 (3.1, 5.4) 0.80 0.97 (0.75-1.24)
56 79/3894 2 (1.6, 2.5) 2 (1.4, 2.7) 56/2443 2.3 (1.7, 3) 1.7 (0.9, 2.4) 0.40 1.16 (0.82-1.63)
58 104/3845 2.7 (2.2, 3.3) 2.5 (1.8, 3.1) 42/2467 1.7 (1.2, 2.3) 1.8 (1, 2.5) 0.01 0.61 (0.43-0.88)
59 165/3672 4.5 (3.8, 5.2) 3.9 (3.1, 4.8) 119/2223 5.4 (4.4, 6.4) 5 (3.7, 6.2) 0.14 1.19 (0.94-1.51)
68 143/3789 3.8 (3.2, 4.4) 3.9 (3, 4.7) 48/2393 2 (1.5, 2.7) 2.5 (1.6, 3.4) <0.001 0.56 (0.40-0.78)
Non-oncogenic c 596/1497 39.8 (36.7, 43.1) 32.5 (29.7, 35.1) 372/1094 34 (30.6, 37.6) 28.9 (25.7, 32) 0.08 0.83 (0.69-1.00)
6 201/3553 5.7 (4.9, 6.5) 5.4 (4.4, 6.3) 104/2258 4.6 (3.8, 5.6) 3.9 (2.8, 5) 0.11 0.82 (0.65-1.04)
11 58/3961 1.5 (1.1, 1.9) 1.2 (0.7, 1.7) 25/2511 1 (0.6, 1.5) 1 (0.4, 1.5) 0.12 0.69 (0.43-1.10)
26 21/4050 0.5 (0.3, 0.8) 0.3 (0.1, 0.6) 6/2541 0.2 (0.1, 0.5) 0.5 (0.1, 0.8) 0.08 0.45 (0.18-1.12)
40 65/3941 1.6 (1.3, 2.1) 1.1 (0.6, 1.5) 44/2479 1.8 (1.3, 2.4) 1.7 (1, 2.4) 0.72 1.07 (0.73-1.58)
42 78/3914 2 (1.6, 2.5) 1.8 (1.2, 2.4) 29/2494 1.2 (0.8, 1.7) 0.8 (0.3, 1.3) 0.01 0.59 (0.38-0.90)
53 198/3630 5.5 (4.7, 6.3) 4.6 (3.7, 5.6) 110/2276 4.8 (4, 5.8) 4.4 (3.2, 5.5) 0.34 0.89 (0.71-1.13)
54 135/3815 3.5 (3, 4.2) 3.8 (2.9, 4.6) 90/2390 3.8 (3, 4.6) 3.6 (2.5, 4.6) 0.56 1.08 (0.83-1.42)
55 85/3873 2.2 (1.8, 2.7) 1.8 (1.2, 2.4) 66/2434 2.7 (2.1, 3.4) 2.5 (1.6, 3.3) 0.16 1.26 (0.91-1.74)
61 177/3628 4.9 (4.2, 5.7) 5 (4, 5.9) 68/2437 2.8 (2.2, 3.5) 3.2 (2.2, 4.2) <0.001 0.59 (0.44-0.78)
62 199/3482 5.7 (4.9, 6.6) 5.6 (4.6, 6.6) 120/2231 5.4 (4.5, 6.4) 5.3 (4, 6.6) 0.69 0.95 (0.76-1.20)
64 11/4067 0.3 (0.1, 0.5) 0.2 (0, 0.4) 3/2557 0.1 (0, 0.3) 0.1 (0, 0.2) 0.18 0.43 (0.12-1.53)
66 150/3708 4 (3.4, 4.7) 3.8 (2.9, 4.6) 112/2261 5 (4.1, 6) 5.5 (4.2, 6.8) 0.08 1.25 (0.98-1.60)
67 42/4020 1 (0.8, 1.4) 0.9 (0.5, 1.3) 22/2528 0.9 (0.5, 1.3) 0.8 (0.3, 1.3) 0.59 0.87 (0.52-1.45)
69 9/4061 0.2 (0.1, 0.4) 0.1 (0, 0.2) 4/2556 0.2 (0, 0.4) 0.1 (0, 0.2) 0.60 0.73 (0.22-2.37)
70 85/3872 2.2 (1.8, 2.7) 2.3 (1.6, 2.9) 41/2467 1.7 (1.2, 2.3) 1.8 (1, 2.5) 0.20 0.78 (0.54-1.14)
71 64/3921 1.6 (1.3, 2.1) 1.7 (1.1, 2.3) 15/2531 0.6 (0.3, 1) 0.7 (0.2, 1.2) <0.001 0.37 (0.21-0.65)
72 63/3928 1.6 (1.2, 2.1) 1.6 (1.1, 2.2) 31/2503 1.2 (0.8, 1.8) 1.3 (0.7, 2) 0.31 0.80 (0.52-1.23)
73 70/3923 1.8 (1.4, 2.3) 1.5 (1, 2) 41/2478 1.7 (1.2, 2.2) 1.6 (0.9, 2.3) 0.71 0.93 (0.63-1.37)
81 113/3774 3 (2.5, 3.6) 3.2 (2.4, 3.9) 49/2447 2 (1.5, 2.6) 2.1 (1.3, 2.8) 0.04 0.70 (0.50-0.98)
82 43/4022 1.1 (0.8, 1.4) 0.7 (0.4, 1.1) 34/2487 1.4 (0.9, 1.9) 1.5 (0.8, 2.1) 0.35 1.24 (0.79-1.95)
83 78/3864 2 (1.6, 2.5) 2 (1.4, 2.6) 45/2453 1.8 (1.3, 2.5) 1.7 (1, 2.4) 0.60 0.91 (0.63-1.31)
84 225/3516 6.4 (5.6, 7.3) 6 (4.9, 7) 163/2125 7.7 (6.5, 8.9) 7.6 (6.1, 9.1) 0.09 1.19 (0.97-1.46)
89 215/3564 6 (5.3, 6.9) 5.9 (4.8, 6.9) 140/2202 6.4 (5.3, 7.5) 5.7 (4.3, 7) 0.51 1.07 (0.87-1.33)
IS39 35/4004 0.9 (0.6, 1.2) 0.6 (0.3, 1) 9/2543 0.4 (0.2, 0.7) 0.2 (0, 0.5) 0.01 0.41 (0.20-0.86)
  1. aAny HPV was defined as at least one of 37 HPV genotypes;
  2. bOncogenic HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68;
  3. cNon-oncogenic HPV types: 6, 11, 26, 40, 42, 53, 54, 55, 61, 62, 64, 66, 67, 69, 70, 71, 72, 73, 81, 82, 83, 84, 89 (CP6108), and IS39;
  4. NOTE: PY, person-year; HR, hazard ratio; CI, confidence interval.