Table 3 Clinical and haematological characteristics of 90 severe and 491 non-severe typhoid fever patients
From: Risk factors for the development of severe typhoid fever in Vietnam
Characteristic | Severe or fatal n = 90 | Non-severe n = 491 | OR | 95% CI | p value |
|---|---|---|---|---|---|
Signs & symptoms | Â | Â | Â | Â | Â |
Abdominal pain | 45 (50.0) | 133 (27.1) | 2.69 | 1.70-4.26 | <0.001 |
Constipation | 29 (32.2) | 105 (21.4) | 1.75 | 1.07-2.86 | 0.025 |
Diarrhoea | 62 (68.9) | 259 (52.7) | 1.98 | 1.23-3.21 | 0.005 |
Vomiting | 30 (33.3) | 86 (17.5) | 2.36 | 1.43-3.87 | 0.001 |
Cough | 21 (23.3) | 110 (22.4) | 1.05 | 0.62-1.80 | 0.846 |
Headache | 42 (46.7) | 178 (36.3) | 1.54 | 0.98-2.42 | 0.061 |
Temperature >40°C | 50 (58.1) | 268 (56.5) | 1.07 | 0.67-1.70 | 0.783 |
Systolic blood pressure <90Â mmHg | 9 (10.0) | 16 (3.3) | 3.30 | 1.41-7.72 | 0.004 |
Hepatomegaly | 62 (68.9) | 241 (49.1) | 2.30 | 1.42-3.71 | 0.001 |
Splenomegaly | 19 (21.1) | 82 (16.7) | 1.34 | 0.76-2.33 | 0.310 |
Rash | 5 (5.6) | 10 (2.0) | 2.83 | 0.94-8.48 | 0.053 |
Haematology | Â | Â | Â | Â | Â |
Haematocrit <30%1 | 23 (26.7) | 49 (11.3) | 2.85 | 1.63-5.01 | <0.001 |
White cell count <4×109/L2 | 10 (11.1) | 30 (6.1) | 1.92 | 0.90-4.07 | 0.086 |
White cell count >15×109/L2 | 5 (5.6) | 6 (1.2) | 4.75 | 1.42-15.90 | 0.006 |
Platelet count <100×109L 3 | 7 (9.9) | 20 (5.8) | 1.77 | 0.72-4.35 | 0.211 |
SGOT > 200 IU/L4 | 33 (63.5) | 30 (17.9) | 7.99 | 4.01-15.91 | <0.001 |
SGPT > 200 IU/L4 | 28 (53.8) | 16 (9.5) | 11.08 | 5.24-23.47 | <0.001 |