Levels of CCL19 and CCL21 in patients and controls. Serum levels of CCL19 (A and
B) and CCL21 (C and
D) is shown for 15 patients with African tick bite fever (ATBF, R. africae) ,16 patients with Mediterranean spotted fever (MSF, R. conorii) and for 14 healthy controls. Blood samples from patients were collected at admission (baseline, basel.) and follow-up (FU), 11–21 days [ATBF] and 28–42 days [MSF] after symptom onset. Twelve of the ATBF were treated with doxycycline for 7 days and all MSF patients were treated with tetracycline for 7 days following admission. Data are given as medians, 25-75 the percentiles and ranges. *p < 0.01 and ***p < 0.001 versus controls. ##p < 0.01 and ###p < 0.001 versus admission.