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Table 3 Sequence differences between HSV-2 HG52 and clinical isolates of HSV-2 in the database

From: Stability of glycoprotein gene sequences of herpes simplex virus type 2 from primary to recurrent human infection, and diversity of the sequences among patients attending an STD clinic

Gene UL27/gB (2715nt) US4/gG (2100nt) US7/gI (1119nt) US8/gE (1638nt)
Total no. of isolates 69 64 49 48
Nucleotide diversity (%) affecting:
1 isolate 1.14 2.24 1.70 1.40
≥2 isolates 0.81 1.52 0.80 0.55
  Position No. of isolates Substitutions, comments Position No. of isolates Substitutions, comments Position No. of isolates Substitutions, comments Position No. of isolates Substitutions, comments
  19 21 A G 104 58 G A 39 5 C T 131 46 ins. GGC CGG AGG
  64-72 or 76-84* 66 del. GCC CCG GCG or GCG GCC CCG 274 26 T C 338 2 A G 341 2 G T
  104 2 G A 329 17 G A 530 2 C T 392 11 T G
  106 2 G A 405 8 C T 618 3 A G 605 6 C A
  117 6 C G 432 22 G C 642 2 A C 1146 8 A G
  146 48 G A 611 10 C T 643 13 C T 1211 14 A C
  179 13 A G 635 13 G A 644 6 C T 1245 2 C T
  210 8 C T 872 3 A G 716 45 T G 1293 2 C T
  211 13 A G 878-880 16 del. TCG 717 11 A C 1621 44** C T
  850 2 C T 891 4 G A       
  989 16 G A 930 50 C T       
  1186 35 G C 982 2 G A       
  2247 47 A C 993 2 G T       
Specification of substitutions affecting ≥2 isolates 2533 29 G C 1045 19 G A       
    1048 64 A G       
    1116 64 A G       
    1125 2 C A       
    1268 37 T C       
    1282-1285 or 1284-1286* 63 del.GCG or GGC       
    1324 7 T C       
    1419 2 A G       
    1470 7 G A       
    1510 3 A G       
    1722 2 G T       
    1758 2 T C       
    1761 7 G C       
    1853 4 G A       
    1994 2 T G       
  1. *Alternative alignments. **Lacking sequences in the 3′- end of a few isolates. Nt nucleotides, Del Deletion, Ins insertion. Positions are numbered from the first nucleotide in the start codon.