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Table 4 Semiquantitative comparative analysis of the various mycobacterial antigens in the individual cases of pulmonary and lymph node tuberculous detected by immunohistochemistry done on formalin fixed paraffin embedded tissues

From: Differential in vivo expression of mycobacterial antigens in Mycobacterium tuberculosisinfected lungs and lymph node tissues

  Secreted antigens Somatic antigens
  MPT32 MPT44 MPT46 MPT51 MPT53 MPT59 MPT63 MPT64 Mce1A Hsp65 MPT57
Lung 1 +++++ - +++++ +++++ +++++ ++++ +++++ +++++ +++ +++++ ++++
Lung 2 +++++ - +++++ +++++ +++++ ++++ +++++ +++++ +++ ++ ++
Lung 3 +++ +++ +++++ ++++ ++++ ++++ ++++ ++++ ++ ++ +++
LN 1 - - - - - SNC - + + +++ +++
LN 2 - SNC - - - - - + +++ +++, SNC +++
LN 3 - - - - - - - + ++ ++++ ++++
LN 4 - - - - - - - + + ++++ +
LN 5 - - - - - - - + +++, SNC +++++ +++++
LN 6 + - - - - SNC - ++ ++ ++++ ++++
LN 7 - - - - - SNC - ++ ++ +++ +
LN 8 - ND - - SNC SNC - ++ + +++ +++
LN 9 - ND - - - - - ++ ++ +++ +++
LN 10 - + - - - - - ++ + +++ ++++
LN 11 - ND - - - + - ++ + +++ +
LN 12 - - - - SNC - + ++ +++ +++ +++
LN 13 + - - - - + - +++ + +++++ +
LN 14 - - - - - - - +++ + +++ +++
LN 15 - + - - SNC - - +++ +++ ++++ ++++
LN 16 + SNC - - - - + +++ ++ ++ ND
LN 17 - - - - - - - ++ + ++ ++++
  1. LN: Lymph node, SNC; staining in the necrotic centres, ND; not determined.
  2. +++++ ~ 80% positive granuloma cells, ++++ ~ 50% positive granuloma cells, +++ 10-25% positive granuloma cells, ++ 2-9% positive granuloma cells, + < 2% positive granuloma cells, - no staining.
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BMC Infectious Diseases

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