Table 3 Scenarios to examine the effect of uncertainty in the model parameters
Variation in | Scenario | Reference |
|---|---|---|
1. Accuracy of screening tests (symptom, CXR) | a. High sensitivity, low specificity* | [5] |
b. Low sensitivity, high specificity* | [5] | |
2. Accuracy of confirmatory tests (SSM, XP) | a. High sensitivity, low specificity* | |
b. Low sensitivity, high specificity* | ||
3. Specificity of SSM, XP | Assume 98% specificity for SSM and XP | [22] |
4. Proportion of persons with negative SSM or XP receiving clinical diagnosis | a. 0% | |
b. 100% | ||
5. Accuracy of clinical diagnosis | Entirely based on CXR diagnosis | [18] |
6. Accuracy of screening tests in different settings | a. Sub Saharan Africa/high HIV-population | [5] |
b. Asia/low HIV population | [5] |