Figure 1
From: A metabolic biosignature of early response to anti-tuberculosis treatment
Work flow for the development and qualification of a urine metabolite biosignature of TB treatment response. Biosignature discovery (left) utilized D0 and M1 samples from two distinct geographical locations. This yielded 45 MFs that decreased in abundance between D0 and M1. Biosignature down selection and qualification (right) also used samples from two geographically distinct locations and expanded the analyses to additional time points after the start of anti-TB therapy.