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Table 2 Main baseline characteristics of herpes zoster and herpes zoster-related pain in each age-group

From: ARIZONA study: is the risk of post-herpetic neuralgia and its burden increased in the most elderly patients?

Age group (years) 70-74 (N = 220) 75-79 (N = 163) 80-84 (N = 137) 85+ (N = 89) p-value
Time-interval between rash onset and herpes zoster diagnosis: % 0.179
 ≤1 day 46.3 34.6 41.9 37.9  
 >1 and ≤2 days 22.7 22.2 24.3 31.0
 >2 and ≤3 days 14.8 16.0 14.0 16.1
 >3 days 16.2 27.2 19.9 14.9
Rash location: % 0.070
 Cranial, cervical, facial, and/or ophthalmic 15.0 16.6 19.0 28.1  
 Thoracic, abdominal and/or sacrolumbar 72.3 66.3 62.8 61.8
 Upper and/or lower limbs 8.2 11.7 8.0 5.6
 Other location and/or combination of previous locations 4.5 5.5 10.2 4.5
Rash severity (quantitative assessment): % 0.775
 Few vesicles 43.9 38.9 43.5 41.2  
 Many vesicles (extensive rash) 56.1 61.1 56.5 58.8
Rash severity (qualitative assessment): %  
 Simple vesicles 86.9 80.3 85.5 81.2 0.294
 Haemorrhagic lesions 7.9 6.4 7.6 12.9 0.328
 Necrotic lesions 3.7 12.1 6.1 4.7 0.650
 Ophthalmic zoster 5.5 8.0 8.8 9.0 0.574
Time interval between pain and HZ vesicles onset: mean (SD) (days) −1.0 (2.3) −0.9 (2.5) −0.8 (2.4) −0.7 (2.1) 0.639
NPSI*: mean (SD) 32.7 (18.5) 29.9 (21.6) 31.1 (18.5) 33.3 (18.0) 0.407
ZBPI: worst pain severity score, mean (SD) 5.4 (2.5) 5.1 (2.8) 5.8 (2.6) 5.5 (2.6) 0.185
Medical treatment: yes (%) 97.7 98.2 100 98.9 0.337
 Antiviral drug 96.3 93.1 92.7 96.6 0.318
 Analgesics 85.6 86.3 88.3 86.4 0.907
  1. NPSI = Neuropathic Pain Symptom Inventory; SD = Standard deviation; ZBPI = Zoster Brief Pain Inventory.
  2. *NPSI score > 30 indicates moderate pain.
  3. from 0, no pain to 10, maximal pain.