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Table 2 Features of cases in the second season, divided in four groups

From: Bordetella pertussis: an underreported pathogen in pediatric respiratory infections, a prospective cohort study

  Clinical suspicion Clinical suspicion Non-suspicion Non-suspicion
RT-PCR positive RT-PCR negative RT-PCR positive RT -PCR negative
N = 7 N = 42 N = 7 N = 250
(Figure 1, group C) (Figure 1, group D) (Figure 1, group E) (Figure 1, group F)
Male, n 4 30 1 147
Age, months, mean (range) 14,8 (1,2-49,6) 4,8 (0,1-21,7) 3,8 (0,6 - 8,7) 7,6 (0,1-89,4)
Clinical features     
In-hospital cases, n 6 (85,7%) 30 (71,4%) 5 (71,4%) 182 (72,8%)
Fever, n 3 (42,9%) 18 (42,9%) 1 (14,2%) 131 (52,4%)
Coughing, n 7 (100%) 41 (97,6%) 7 (100%) 207 (82,8%)
Rhinorrhea, n 7 (100%) 39 (92,9%) 7 (100%) 231 (92,4%)
Paroxysmal cough, n 6 (85,7%) 25 (59,5) 1 (14,2%) 27 (10,8%)
CRP > 40 mg/L, n 0 (0%) 3 (7,1%) 1 (14,2%) 26 (10,4%)
Oxygen therapy necessary, n 2 (28,6%) 15 (35,7%) 2 (28,6%) 105 (42,0 %)
Nasogastric feeding, n 1 (14,3%) 5 (11,9%) 0 (0,0%) 27 (10,8%)
Wheezing, n 3 (42,9%) 15 (35,7%) 1 (14,2%) 113 (45,2%)
Apnoe, n 0 (0%) 3 (7,1%) 0 (0,0%) 10 (4,0%)
Days of illness, mean (range) 18,3 (5–37) 9,7 (2–42) 10,4 (5–18) 8,3 (1–35)
Disease severity score, mean (range) 9,9 (0–19) 11,7 (0–24) 9,6 (3–18) 13,4 (0–27)
Disease severity score     
<6 2 9 2 65
7-13 3 16 3 55
14-19 2 14 2 75
>20 0 3 0 55
Clinical diagnosis     
Exclusively URTI 0 23 4 133
Exclusively LRTI 0 0 0 1
Combined URTI/LRTI 7 18 3 106
No URTI or LRTI 0 1 0 10
Pertussis diagnosis     
PCR throat swab material, n 4 x 0 x
PCR NWS, n 3 x 7 x
Serology, positive, n 1 x 0 x
Culture, positive n 0 x 0 x
Viral (co)infection     
None 1 7 2 37
1 virus 6 21 3 146
≥ 2 virusses 0 14 2 67
Antibiotic therapy     
None 0 26 4 158
Amoxicillin, n 1 9 2 94
Claritromycine, n 7 7 1 8