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Table 1 Relationship between host genotype and parasite var gene expression

From: An assessment of the impact of host polymorphisms on Plasmodium falciparum vargene expression patterns among Kenyan children

   Cys2 vargroup Group A-like subgroup MFK + REY- subgroup MFK-REY + subgroup MFK-REY- subgroup
Host polymorphism Type, no. in dataset Beta (95% CI), pvalue Beta (95% CI), pvalue Beta (95% CI), pvalue Beta (95% CI), pvalue Beta (95% CI), pvalue
ABO blood group Blood group O, 108 0 0 0 0 0
Blood group A, 76 0.004 (-0.10, 0.11), p = 0.9 -0.004 (-0.10, 0.09), p = 0.9 -0.004 (-0.09, 0.08), p = 0.9 0.01 (-0.07, 0.09), p = 0.8 -0.01 (-0.09, 0.06), p = 0.7
Blood group B, 54 0.05 (-0.07, 0.16), p = 0.4 0.08 (-0.02, 0.19), p = 0.1 0.08 (-0.02, 0.17), p = 0.1 0.01 (-0.08, 0.09), p = 0.8 -0.01 (-0.09, 0.07), p = 0.8
Blood group AB, 12 0.13 (-0.08, 0.34), p = 0.2 0.25 (0.07, 0.44), p = 0.008 0.07 (-0.10, 0.24), p = 0.4 0.06 (-0.10, 0.21), p = 0.5 0.02 (-0.12, 0.17), p = 0.8
CD36 (T188G) Wild type (T/T), 153 0 0 0 0 0
Heterozygous (T/G), 22 0.08 (-0.06, 0.23), p = 0.3 0.03 (-0.10, 0.15), p = 0.7 0.03 (-0.08, 0.14), p = 0.6 -0.01 (-0.12, 0.11), p = 0.9 0.07 (-0.04, 0.18), p = 0.2
Homozygous (G/G), 1 ND ND ND ND ND
ICAM1 (K29M) Wild type (K29/K29), 79 0 0 0 0 0
Heterozygous (K29/M29), 74 -0.03 (-0.13, 0.07), p = 0.6 -0.07 (-0.16, 0.02), p = 0.1 -0.03 (-0.11, 0.05), p = 0.4 0.04 (-0.04, 0.12), p = 0.3 -0.06 (-0.14, 0.01), p = 0.1
Homozygous (M29/M29), 23 -0.05 (-0.21, 0.10), p = 0.5 -0.01 (-0.15, 0.12), p = 0.9 0.06 (-0.06, 0.17), p = 0.3 -0.07 (-0.20, 0.05), p = 0.2 -0.09 (-0.20, 0.03), p = 0.1
HbS Wild type (HbAA), 198 0 0 0 0 0
Heterozygous (HbAS), 12 -0.19 (-0.40, 0.01), p = 0.07 -0.18 (-0.37, 0.01), p = 0.07 -0.08 (-0.25, 0.09), p = 0.4 -0.08 (-0.25, 0.08), p = 0.3 -0.10 (-0.25, 0.05), p = 0.2
Homozygous (HbSS), 1 ND ND ND ND ND
Alpha-thalassaemia Wild type (αα/αα), 77 0 0 0 0 0
Heterozygous (-α/αα), 106 0.10 (-0.001, 0.20), p = 0.05 0.06 (-0.03, 0.16), p = 0.2 0.07 (-0.01, 0.15), p = 0.08 -0.01 (-0.09, 0.07), p = 0.8 0.04 (-0.03, 0.11), p = 0.3
Homozygous (-α/-α), 31 0.03 (-0.11, 0.18), p = 0.6 0.02 (-0.11, 0.16), p = 0.7 0.03 (-0.09, 0.14), p = 0.6 -0.05 (-0.17, 0.06), p = 0.3 0.06 (-0.04, 0.17), p = 0.2
  1. Results from linear regression models predicting var expression levels using the various host polymorphisms are shown. In the case of ABO blood groups, binary variables for blood group A, B and AB were used simultaneously as explanatory variables such that the results are presented relative to blood group O. For the CD36 T188G polymorphism, the ICAM1 K29M polymorphism and alpha-thalassaemia both the heterozygous and homozygous allelic states were used simultaneously as explanatory variables such that the results are relative to the wild type of each host molecule. ND, not done.