Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis

BMC Infectious Diseases

Table 2 Clinical data of pulmonary tuberculosis patients (N = 187) and normal reference ranges

	PTB patients (mean ± SD)	Normal reference ranges	Median	P ^a
Total protein (g/L)	68.32 ± 6.66	64.00 − 83.00	72.88	< 0.001^**
Albumin (g/L)	37.94 ± 5.13	36.00 − 52.00	43.27	< 0.001^**
Globulin (g/L)	30.27 ± 5.60	22.00 − 34.00	27.35	< 0.001^**
A/G	1.29 ± 0.32	1.20 − 2.50	1.73	< 0.001^**
CRP (mg/L)	29.69 ± 38.72	0.00 − 0.82	0.41	< 0.001^**
Prealbumin (g/L)	0.18 ± 0.08	0.15 − 0.36	0.23	< 0.001^**
Fibrinogen (g/L)	5.69 ± 2.23	1.90 − 5.60	3.26	< 0.001^**
Triglyceride (mmol/L)	1.06 ± 0.67	0.56 − 1.69	1.05	0.001^**
LDH (U/L)	167.55 ± 54.74	100.00 − 240.00	154.92	0.064
HDL-C (mmol/L)	1.03 ± 0.34	1.03 − 1.55	1.26	< 0.001^**
LDL-C (mmol/L)	2.31 ± 0.81	0.00 − 3.10	1.55	< 0.001^**
Lipoprotein (mg/L)	270.60 ± 275.90	0.00 − 300.00	150.00	0.004^**
APOA1 (g/L)	1.05 ± 0.23	1.20 − 1.60	1.39	< 0.001^**
APOB (g/L)	0.76 ± 0.20	0.80 − 1.05	0.92	< 0.001^**
IgG (g/L)	14.05 ± 3.60	11.50 − 14.22	12.79	0.007^**
IgA (g/L)	2.84 ± 1.37	1.70 − 3.25	2.35	0.044^*
IgM (g/L)	1.21 ± 0.57	0.73 − 1.17	0.92	< 0.001^**
Complement 4 (mg/L)	377.78 ± 80.38	100.00 − 400.00	200.00	< 0.001^**
Complement 3 (g/L)	1.04 ± 0.24	0.83 − 1.77	1.21	< 0.001^**

A P-value of less than 0.05 indicates statistical significance. PTB: pulmonary tuberculosis; N: number of subjects; A/G: Albumin/ Globulin; CRP: C-reactive protein; LDH: Lactate dehydrogenase; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; APOA1: apolipoprotein A1; APOB: apolipoprotein B; ^* P < 0.05; ^** P < 0.01. ^a P value between TB patients and normal reference range, for one-sample t-test after taking the logarithm then compare to the median.