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Table 3 Predictors of early liver enzyme elevation and anaemia after two weeks of antiretroviral therapy

From: Evaluating the utility of early laboratory monitoring of antiretroviral-induced haematological and hepatic toxicity in HIV-infected persons in Cameroon

Characteristics Crude odd ratios (95% Confidence Interval) p-value Adjusted odd ratios (95% Confidence Interval) p-value
Early liver enzyme elevation
NRTI-based regimens     
AZT-based 1   1  
D4T-based 18.3 (0.91-370.28) 0.058 36.52 (1.44-924.38) 0.029
ABC-based 1   1  
TDF-based 1.83 (0.42-8.07) 0.423 3.43 (0.61-19.21) 0.160
Fasting blood sugar (mg/dl)     
<126 1   1  
≥126 6.40 (1.02-40.12) 0.047 6.26 (1.00-39.30) 0.50
Early anaemia
Baseline haemoglobin (g/dl)     
≥10 1   1  
<10 25.6 (8.61-76.17) <0.0001 60.08 (13.36-270.20) <0.0001
Body weight (kg)     
<60 1   1  
≥60 0.32 (0.12-0.88) 0.027 0.28 (0.09-0.83) 0.022
Use of ITN     
No 1   1  
Yes 4.41 (1.43-13.64) 0.010 4.60 (1.35-15.71) 0.015
NRTI-based regimens     
AZT-based 1   1  
D4T-based 1   1  
ABC-based 1   1 0.252
TDF-based 3.38 (1.56-7.32) 0.002 2.01 (0.61-6.64)  
Use of haematinics     
No 1   1  
Yes 3.74 (1.75-8.00) 0.001 1.06 (0.32-3.49) 0.921
Marital status     
Single 1   1  
Married 0.43 (0.18-0.99) 0.049 0.54 (0.14-2.01) 0.357
Divorced 1   1  
Widowed 0.47 (0.15-1.53) 0.212 0.81 (0.15-4.42) 0.804
  1. ITN = insecticide treated nets, NRTI = nucleotide reverse transcriptase inhibitor, NNRTI = non-nucleotide reverse transcriptase inhibitor, ABC = abacavir, D4T = stavudine, AZT = zidovudine, TDF = tenofovir, EFV = efavirenz, NVP = nevirapine.