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Table 2 Positive post-travel IGRA* and TST** results in a cohort of 516 travellers to TB-endemic countries, December 2008-September 2011

From: Screening travellers to high-endemic countries for infection with Mycobacterium tuberculosis using interferon gamma release assay; a prospective study

Traveller Travel IGRA (IU/ml) TST (mm) Follow-up at TB department
  Age range (y) BCG Travel history Reason Destination Duration (days) Pre-travel Post-travel Interval return and IGRA (days) Conversion Pre-travel Post-travel Interval return and TST (days) Conversion  
1 31-35 no Asia: 3w Latin America: 4w non medical work SE Asia 365 −0,05 1.15 29 yes nt 8 39 no Volunteer work, non-medical. TST performed in 2000: 0 mm. Started preventive treatment 43 days post travel.
2 26-30 no Africa: 1w tourism SE Asia 172 −0,03 0,56 25 yes nt 2 37 no IGRA repeated 85 days post travel: 0.21 IU/ml. No preventive treatment was started.
3 26-30 no no non medical work SE Asia 150 nt −0,01 27 no 2 13 27 yes IGRA repeated 55 days post travel: 0.002 IU/ml. According to Dutch guidelines: no preventive treatment was started since IGRA was negative.
4 41-45 no Asia: 3 mo Africa: 5 w non medical work SE Asia 356 nt 0,02 28 no 2 15 112 yes No follow-up.
5 18-20 no no tourism SE Asia/ East Asia 93 nt 0,04 38 no 0 11 90 yes No follow-up IGRA. X-ray 94 days post travel showed no abnormalities; no preventive treatment.
6 36-40 no Asia: 2 mo Latin America: 9 mo tourism South Asia 180 nt −0,05 42 no 0 10 63 yes No follow-up. No preventive treatment.
7 21-25 no Africa: 6 w medical setting Sub-Sahara Africa 118 nt 0,11 18 no 0 10 79 yes Medical student in a hospital in East-Africa for 3 months. IGRA repeated 79 days post travel: 7.47 IU/ml; Preventive therapy was started.
8 26-30 no Asia: 6 w Latin America: 5 mo tourism Central America 147 nt −0,01 20 no nt 18 20 unknown No IGRA follow-up. X thorax showed no abnormalities. No preventive treatment. (TST performed in 2007 was 6 mm).
9 41-45 no Asia: 6 mo Africa: 1 mo non medical work sub-Sahara Africa 242 nt −0,01 51 no nt 11 51 unknown No follow-up. According to Dutch guidelines: no preventive treatment was started since IGRA was negative.
10 21- 25 no Africa: 10 mo tourism Central America 214 nt 0.00 21 no nt 10 61 unknown Advised to have IGRA repeated but no compliance.
  1. IGRA: interferon gamma release assay; TST: tuberculin skin test; TB: tuberculosis; y: years; w: weeks; mo: months; nt: not tested; *: of all 516 samples tested; **: of all 261 TST results.