From: How to treat severe infections in critically ill neutropenic patients?
Antibiotherapy | Indications | Grade of recommendation |
---|---|---|
Antipseudomonal β-lactam agent | All high risk patients with neutropenic fever | A-I |
- Carbapenem (meropenem or imipenem-cilastatin) | ||
Piperacillin-tazobactam | ||
Aminoglycosides | Hemodynamic instability | B-III |
Vancomycin | - Suspected catheter-related infections | A-I |
- Skin or soft-tissue infection | ||
- Hemodynamic instability | ||
Vancomycin, linezolid or daptomycin | Risk of methicillin-resistant Staphylococcus aureus | B-III |
Linezolid or daptomycin | Risk of vancomycine-resistant enterococcus | B-III |
Carbapenem | Risk of extended-spectrum β-lactamase-producing gram negative bacteria | B-III |
Polymyxin-colistin or tigecycline | Risk of Klebsiella pneumonia carbapenemase (KPC) | C-III |
- Ciprofloxacin + clindamycin | Penicillin-allergic patients | A-II |
- Aztreonam + vancomycin |  |  |