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Table 1 Empiric antibiotic therapy in high risk patients with neutropenic fever (adapted from the IDSA guidelines[4])

From: How to treat severe infections in critically ill neutropenic patients?

Antibiotherapy

Indications

Grade of recommendation

Antipseudomonal β-lactam agent

All high risk patients with neutropenic fever

A-I

- Carbapenem (meropenem or imipenem-cilastatin)

Piperacillin-tazobactam

Aminoglycosides

Hemodynamic instability

B-III

Vancomycin

- Suspected catheter-related infections

A-I

- Skin or soft-tissue infection

- Hemodynamic instability

Vancomycin, linezolid or daptomycin

Risk of methicillin-resistant Staphylococcus aureus

B-III

Linezolid or daptomycin

Risk of vancomycine-resistant enterococcus

B-III

Carbapenem

Risk of extended-spectrum β-lactamase-producing gram negative bacteria

B-III

Polymyxin-colistin or tigecycline

Risk of Klebsiella pneumonia carbapenemase (KPC)

C-III

- Ciprofloxacin + clindamycin

Penicillin-allergic patients

A-II

- Aztreonam + vancomycin

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