Table 2 Positive cytokine responses per antigen before and after 2 weeks of TB treatment
No. of positive responders per antigen [n1/N2(%)] | |||||
|---|---|---|---|---|---|
SEB | E6/C10 | Rv1733 | Rv2029 | Rv2628 | |
Granzyme B | |||||
Before | 19/19 (100) | 13/19 (68.4) | 13/18 (72.2) | 7/11 (63.6) | 7/10 (70) |
After 2wks | 14/15 (93.3) | 12/15 (80.0) | 9/10 (90.0) | 7/7 (100.0) | 5/5 (100) |
P value | 0.4412 | 0.6974 | 0.3746 | 0.1193 | 0.5055 |
IFN-γ | |||||
Before | 18/19 (94.7) | 16/19 (84.2) | 15/18 (83.3) | 8/11 (72.7) | 8/10 (80.0) |
After 2wks | 12/15 (80.0) | 13/15 (86.6) | 10/10 (100) | 7/7 (100) | 5/5 (100) |
P value | 0.2994 | 1.0 | 0.5330 | 0.2451 | 0.5238 |
IL-10 | |||||
Before | 18/19 (94.7) | 14/19 (73.7) | 12/18 (66.7) | 7/11 (63.6) | 5/10 (50.0) |
After 2wks | 12/15 (80) | 9/15 (60.0) | 7/10 (70.0) | 4/7 (57.1) | 5/5 (100) |
P value | 0.2994 | 0.4748 | 1.0 | 1.0 | 0.1009 |
IL-17 | |||||
Before | 19/19 (100) | 13/19 (68.4) | 14/18 (77.8) | 6/11 (54.5) | 8/10 (80.0) |
After 2wks | 13/15 (86.6) | 12/15 (80.0) | 9/10 (90.0) | 6/7 (85.7) | 5/5 (100) |
P value | 0.1872 | 0.6974 | 0.6264 | 0.3156 | 0.5238 |
sIL-2R-α | |||||
Before | 18/19 (94.7) | 14/20 (70.0) | 12/18 (66.7) | 7/11 (63.6) | 8/10 (80.0) |
After 2wks | 11/15 (73.3) | 12/15 (80.0) | 9/10 (90.0) | 6/7 (85.6) | 5/5 (100) |
P value | 0.1458 | 0.7003 | 0.3642 | 0.5956 | 0.5238 |
TNF-α | |||||
Before | 16/19 (84.2) | 13/19 (68.4) | 12/18 (66.7) | 7/11 (63.6) | 7/10 (70.0) |
After 2wks | 11/15 (73.3) | 9/10 (90.0) | 9/10 (90.0) | 5/7 (71.4) | 5/5 (100) |
P value | 0.6722 | 0.3667 | 0.3642 | 1.0 | 0.5055 |