Figure 2

ESAT-6/CFP-10 fusion protein and latency associated Rv1733 induce comparable levels of the 6 cytokines. Cytokine levels induced by ESAT-6/CFP-10 (EC) fusion protein and Latency associated Rv1733 at baseline (T0) and 2 weeks (T1) of treatment were compared using the Wilcoxon matched pairs test in patients who had data for both time points available (n = 9). Cytokine levels were obtained after subtracting values in un-stimulated wells from stimulated wells and negative values were converted to zero. The box plots show the 25th, 50th, and 75th percentiles, and the whiskers represent the minimum and maximum levels of cytokine (pg/ml) induced by each stimulus. For each cytokine, the comparison was done between the amount secreted by ESAT-6/CFP-10 vrs Rv1733 at baseline (T0) and that between ESAT-6/CFP-10 vrs Rv1733 at week two (T1). P values of <0.05 were considered significant.