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Table 4 Arguments pro and against a short duration of antibiotic therapy

From: Treatment of bloodstream infections in ICUs

Arguments for a short treatment Arguments for a longer treatment
No comorbid conditions Immune depression
Source control No source control
Low MICs, high bactericidal titers MDR , XDR bacterias
Initial appropriate therapy Low bactericidal titers
Easy PK and tissue diffusion Poor PK and tissue diffusion
Source control appropriate Foreign materials
No foreign material Slow, partial clinical response
Rapid clinical improvement