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Table 3 Suggested intravenous of initial selected antibiotic doses in critically ill patients during the first 24 hours of treatment of bacteremia with severe sepsis in ICU (to be adapted in case of kidney injury and renal replacement therapy) (adapted from[61, 6366]

From: Treatment of bloodstream infections in ICUs

Antibiotic class  
Aminoglycosides Amikacin 25 mg/kg
Gentamicin 7 mg/kg
Interval administration and doses adjusted according to TDM
Fluoroquinolones Ciprofloxacin 400 8 hourly
Colistin 9-12 MU (720-960 mg) loading dose followed by 480 mg 12 hourly if patient without kidney injury.
Beta-lactams Cefepime 2 g 8 hourly
Ceftazidime 2 g 6 hourly
Imipenem 1 g 6-8 hourly
Meropenem 1 g 6-8 hourly
Ertapenem 1 g 12 hourly
Piperacillin-Tazobactam 4.5 g 6 hourly
Glycopeptides Vancomycin 35 mg/kg in a 1 hour infusion loading dose followed by 30 mg/kg continuous infusion
Daptomycin 8-12 mg/kg 24 hourly
Tigecyclin 200 mg followed by 100 mg 12 hourly when borderline susceptibility is suspected