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Table 3 Suggested intravenous of initial selected antibiotic doses in critically ill patients during the first 24 hours of treatment of bacteremia with severe sepsis in ICU (to be adapted in case of kidney injury and renal replacement therapy) (adapted from[61, 63–66]

From: Treatment of bloodstream infections in ICUs

Antibiotic class

 

Aminoglycosides

Amikacin 25 mg/kg

Gentamicin 7 mg/kg

Interval administration and doses adjusted according to TDM

Fluoroquinolones

Ciprofloxacin 400 8 hourly

Colistin

9-12 MU (720-960 mg) loading dose followed by 480 mg 12 hourly if patient without kidney injury.

Beta-lactams

Cefepime 2 g 8 hourly

Ceftazidime 2 g 6 hourly

Imipenem 1 g 6-8 hourly

Meropenem 1 g 6-8 hourly

Ertapenem 1 g 12 hourly

Piperacillin-Tazobactam 4.5 g 6 hourly

Glycopeptides

Vancomycin 35 mg/kg in a 1 hour infusion loading dose followed by 30 mg/kg continuous infusion

Daptomycin

8-12 mg/kg 24 hourly

Tigecyclin

200 mg followed by 100 mg 12 hourly when borderline susceptibility is suspected