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Table 1 Cytokine production by splenocytes of immunized Kunming mice after stimulation by Toxoplasma lysate antigen (TLA)

From: Protective efficacy of Toxoplasma gondiicalcium-dependent protein kinase 1 (TgCDPK1) adjuvated with recombinant IL-15 and IL-21 against experimental toxoplasmosis in mice

Group (n = 3) Cytokine production (pg/ml) Proliferation (SI)
  IFN-γ IL-2 IL-4 IL-10  
pVAX-CDPK1 + pVAX-IL-21-IL-15 867.78 ± 15.63A* 532.54 ± 23.06A 154.44 ± 11.16A 131.04 ± 10.31A 5.57 ± 0.01A
pVAX-IL-21-IL-15 505.12 ± 32.72B 314.77 ± 27.06B 105.15 ± 16.82B 96.54 ± 20.03B 3.79 ± 0.05B
pVAX-CDPK1 563.65 ± 12.97C 353.12 ± 10.93C 111.94 ± 8.90B 109.72 ± 8.65B 4.19 ± 0.14C
pVAX I 53.02 ± 3.73D 52.04 ± 1.43D 51.01 ± 1.08C 51.13 ± 1.70C 1.05 ± 0.00D
PBS 52.92 ± 2.73D 51.49 ± 2.67D 49.84 ± 1.37C 50.20 ± 1.24C 1.04 ± 0.07D
Control 52.53 ± 2.43D 51.56 ± 1.43D 49.50 ± 1.79C 49.75 ± 1.16C 1.03 ± 0.03D
  1. SI stimulation index.
  2. Splenocytes from 3 mice were harvested 2 weeks after the last immunization.
  3. Values for IFN-γ are after 96 h, values for IL-2 and IL-4 are after 24 h, and values for IL-10 are after 72 h.
  4. *The same superscript letter “D” on the shoulders of experimental data means no statistically significant difference (P > 0.05) among different experimental groups from the same measurement, while different letter including A, B, C means statistically significant difference among different experimental groups from the same measurement (P < 0.05).